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Substance Name: Opc 21268
RN: 131631-89-5
InChIKey: KSNUCNRMDYJBKT-UHFFFAOYSA-N

Note

  • Vasopressin V1 receptor antagonist.

Classification Codes

  • Antidiuretic Hormone Receptor Antagonists
  • Drug / Therapeutic Agent
  • Natriuretic Agents

Molecular Formula

  • C26-H31-N3-O4

Molecular Weight

  • 449.548
 
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Names and Synonyms

Name of Substance

  • OPC 21268

Synonyms

  • 1-(1-(4-(3-Acetylaminopropoxy)benzoyl)-4-piperidyl)-3,4-dihydro-2(1H)-quinolinone
  • OPC 21268

Systematic Name

  • Acetamide, N-(3-(4-((4-(3,4-dihydro-2-oxo-1(2H)-quinolinyl)-1-piperidinyl)carbonyl)phenoxy)propyl)-

Registry Numbers

CAS Registry Number

  • 131631-89-5

System Generated Number

  • 0131631895

Structure Descriptors

InChI

1S/C26H31N3O4/c1-19(30)27-15-4-18-33-23-10-7-21(8-11-23)26(32)28-16-13-22(14-17-28)29-24-6-3-2-5-20(24)9-12-25(29)31/h2-3,5-8,10-11,22H,4,9,12-18H2,1H3,(H,27,30)

InChIKey

KSNUCNRMDYJBKT-UHFFFAOYSA-N

Smiles

c1(ccc(C(=O)N2CCC(CC2)N2C(CCc3c2cccc3)=O)cc1)OCCCNC(C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg)   Cardiovascular Drug Reviews. Vol. 11, Pg. 271, 1993.
rat LD50 oral > 2gm/kg (2000mg/kg)   Cardiovascular Drug Reviews. Vol. 11, Pg. 271, 1993.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg)   Cardiovascular Drug Reviews. Vol. 11, Pg. 271, 1993.