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Substance Name: Trimetazidine hydrochloride [JAN]
RN: 13171-25-0
UNII: 48V6723Z1P
InChIKey: VYFLPFGUVGMBEP-UHFFFAOYSA-N

Note

  • A vasodilator used in angina of effort or ischemic heart disease.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C14-H22-N2-O3.2Cl-H

Molecular Weight

  • 339.261
 
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Names and Synonyms

Name of Substance

  • Trimetazidine dihydrochloride
  • Trimetazidine hydrochloride [JAN]

Synonyms

  • 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride
  • Adexor
  • EINECS 236-117-0
  • Kyurinett
  • Lubomail
  • S 4004
  • Trimetajust
  • Trimetazidine dihydrochloride
  • Trimetazidine HCl
  • Trimetazidine hydrochloride
  • UNII-48V6723Z1P
  • Vastarel
  • Yosimilon

Systematic Names

  • Piperazine, 1-((2,3,4-trimethoxyphenyl)methyl)-, dihydrochloride (9CI)
  • Piperazine, 1-(2,3,4-trimethoxybenzyl)-, dihydrochloride
  • Trimetazidine dihydrochloride

Registry Numbers

CAS Registry Number

  • 13171-25-0

FDA UNII

  • 48V6723Z1P

System Generated Number

  • 0013171250

Molecular Formulas

Molecular Formula

  • C14-H22-N2-O3.2Cl-H

Molecular Formula Fragments

  • C14-H22-N2-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C14H22N2O3.2ClH/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16;;/h4-5,15H,6-10H2,1-3H3;2*1H

InChIKey

VYFLPFGUVGMBEP-UHFFFAOYSA-N

Smiles

c1(c(c(CN2CCNCC2)ccc1OC)OC)OC.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 305mg/kg (305mg/kg)   United States Patent Document. Vol. #3262852,
mouse LD50 intravenous 125mg/kg (125mg/kg)   United States Patent Document. Vol. #3262852,
mouse LD50 oral 1550mg/kg (1550mg/kg)   Drugs in Japan Vol. 6, Pg. 527, 1982.
mouse LD50 subcutaneous 410mg/kg (410mg/kg)   Drugs in Japan Vol. 6, Pg. 527, 1982.
rat LD50 intraperitoneal 345mg/kg (345mg/kg)   Drugs in Japan Vol. 6, Pg. 527, 1982.
rat LD50 oral 1700mg/kg (1700mg/kg)   Drugs in Japan Vol. 6, Pg. 527, 1982.
rat LD50 subcutaneous 1500mg/kg (1500mg/kg)   Drugs in Japan Vol. 6, Pg. 527, 1982.