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Substance Name: Pheniramine maleate [USAN:USP]
RN: 132-20-7
UNII: NYW905655B
InChIKey: SSOXZAQUVINQSA-BTJKTKAUSA-N

Note

  • One of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus.

Molecular Formula

  • C16-H20-N2.C4-H4-O4

Molecular Weight

  • 356.4196
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Pheniramine maleate [USAN:USP]

Synonyms

  • 1-(N,N-Dimethylamino)-3-(phenyl-3-alpha-pyridyl)propane maleate
  • 1-Phenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
  • 2-(alpha-(2-(Dimethylamino)ethyl)benzyl)pyridine, bimaleate
  • 2-(alpha-(2-(Dimethylamino)ethyl)benzyl)pyridine, maleate
  • 2-(alpha-(2-Dimethylaminoethyl)benzyl)pyridine bimaleate
  • 2-Pyridinepropanamine, N,N-dimethyl-gamma-phenyl-, (Z)-2-butenedioate (1:1)
  • Avil-retard
  • CCRIS 6265
  • Daneral
  • EINECS 205-051-4
  • HO 11513
  • Inhiston
  • Metron
  • N,N-Dimethyl-3-phenyl-3-(2-pyridyl)propylamine hydrogen maleate
  • Naphcon A
  • Naphcon-A
  • Pheniramine hydrogen maleate
  • Pheniramine maleate
  • Phenyl(2-pyridyl)(beta-N,N-dimethylaminomethyl) methane maleate
  • PM 241
  • Prophenpyridamine maleate
  • Trimeton
  • Trimetose
  • UNII-NYW905655B

Systematic Names

  • 2-(alpha-(2-Dimethylaminoethyl)benzyl)pyridine bimaleate
  • 2-Pyridinepropanamine, N,N-dimethyl-gamma-phenyl-, (2Z)-2-butenedioate (1:1)
  • 2-Pyridinepropanamine, N,N-dimethyl-gamma-phenyl-, (Z)-2-butenedioate (1:1)
  • Pheniramine hydrogen maleate
  • Pheniramine maleate
  • Pyridine, 2-(alpha-(2-(dimethylamino)ethyl)benzyl)-, maleate (1:1)

Mixture Names

  • Dristan Nasal Spray
  • Ru-Tuss Hydrocodone Liquid

Registry Numbers

CAS Registry Number

  • 132-20-7

FDA UNII

  • NYW905655B

Other Registry Number

  • 155683-11-7

Related Registry Number

  • 86-21-5 (Parent)

System Generated Number

  • 0000132207

Molecular Formulas

Molecular Formula

  • C16-H20-N2.C4-H4-O4

Molecular Formula Fragments

  • C16-H20-N2
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C16H20N2.C4H4O4/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16;5-3(6)1-2-4(7)8/h3-10,12,15H,11,13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChIKey

SSOXZAQUVINQSA-BTJKTKAUSA-N

Smiles

CN(C)CCC(c1ccccc1)c2ccccn2.OC(=O)\C=C/C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child LDLo oral 30mg/kg (30mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANTIPSYCHOTIC

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Archiv fuer Toxikologie. Vol. 29, Pg. 317, 1972.
dog LDLo intravenous 111mg/kg (111mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

CARDIAC: CHANGE IN RATE
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
guinea pig LD50 intravenous 72mg/kg (72mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958.
guinea pig LD50 oral 270mg/kg (270mg/kg)   Journal of Allergy. Vol. 27, Pg. 57, 1956.
mouse LD50 oral 268mg/kg (268mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: AGGRESSION

BEHAVIORAL: TREMOR
Kurume Igakkai Zasshi. Journal of the Kurume Medical Association. Vol. 43, Pg. 168, 1980.
rat LD50 oral 520mg/kg (520mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: AGGRESSION
Kurume Igakkai Zasshi. Journal of the Kurume Medical Association. Vol. 43, Pg. 168, 1980.
rat LDLo subcutaneous 200mg/kg (200mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: TREMOR
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 144, Pg. 887, 1950.