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Substance Name: Chlorphenamine [INN:BAN]
RN: 132-22-9
UNII: 3U6IO1965U
InChIKey: SOYKEARSMXGVTM-UHFFFAOYSA-N
Note
- A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
Molecular Formula
- C16-H19-Cl-N2
Molecular Weight
- 274.7931
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- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Allergic Agents
- Antipruritics
- Dermatologic Agents
- Drug / Therapeutic Agent
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Neurotransmitter Agents
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Names and Synonyms
Results Name
- Chlorphenamine [INN:BAN]
Name of Substance
- Chlorphenamine [INN:BAN]
- Chlorpheniramine
- Chlorpheniramine polistirex [USAN]
MeSH Heading
- Chlorpheniramine
Synonyms
- 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
- 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine
- 2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine
- 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-
- 3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
- 4-Chloropheniramine
- Allergican
- Allergisan
- Chloropheniramine
- Chlorophenylpyridamine
- Chloropiril
- Chloroprophenpyridamine
- Chlorphenamine
- Chlorphenaminum
- Chlorphenaminum [INN-Latin]
- Chlorpheniramine
- Chlorpheniramine polistirex
- Chlorpheniraminum
- Chlorprophenpyridamine
- Clorfenamina
- Clorfenamina [INN-Spanish]
- Clorfeniramina
- Clorfeniramina [Italian]
- Cloropiril
- EINECS 205-054-0
- gamma-(4-Chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine
- gamma-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine
- Haynon
- Histadur
- HSDB 3032
- Polaronil
- Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-
- UNII-3U6IO1965U
Systematic Names
- 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-
- Chlorphenamine
- Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-
Registry Numbers
CAS Registry Number
- 132-22-9
FDA UNII
- 3U6IO1965U
Other Registry Numbers
- 42882-96-2
- 46970-45-0
System Generated Number
- 0000132229
Structure Descriptors
InChI
InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3InChIKey
SOYKEARSMXGVTM-UHFFFAOYSA-NSmiles
CN(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 125mg/kg (125mg/kg) | Yakugaku Zasshi. Journal of Pharmacy. Vol. 92, Pg. 1339, 1972. | |
mouse | LD50 | intravenous | 20mg/kg (20mg/kg) | Medizinische Welt. Vol. 17, Pg. 2791, 1966. | |
mouse | LD50 | oral | 121mg/kg (121mg/kg) | Medizinische Welt. Vol. 17, Pg. 2791, 1966. | |
mouse | LD50 | subcutaneous | 160mg/kg (160mg/kg) | Bollettino Chimico Farmaceutico. Vol. 111, Pg. 293, 1972. | |
rabbit | LD50 | intravenous | 22mg/kg (22mg/kg) | Medizinische Welt. Vol. 17, Pg. 2791, 1966. | |
rat | LD50 | oral | 118mg/kg (118mg/kg) | Medizinische Welt. Vol. 17, Pg. 2791, 1966. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
pKa Dissociation Constant | 9.13 | (none) | 25 | EXP |
log P (octanol-water) | 3.38 | (none) | EXP | |
Water Solubility | 5500 | mg/L | 37 | EXP |
Vapor Pressure | 1.12E-05 | mm Hg | 25 | EST |
Henry's Law Constant | 4.07E-10 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 8.55E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.