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Substance Name: Benzydamine hydrochloride [USAN:JAN]
RN: 132-69-4
UNII: K2GI407R4Q
InChIKey: HNNIWKQLJSNAEQ-UHFFFAOYSA-N

Note

  • A benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat.

Molecular Formula

  • C19-H23-N3-O.Cl-H

Molecular Weight

  • 345.872
 

Classification Codes

  • Analgesic
  • Anti-Inflammatory
  • Antipyretic
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect
  • Skin / Eye Irritant
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Names and Synonyms

Name of Substance

  • Benzydamine hydrochloride [USAN:JAN]

Synonyms

  • 1-Benzyl-3-(3-(dimethylamino)propoxy)-1H-indazole hydrochloride
  • 1-Benzyl-3-(3-(dimethylamino)propoxy)-1H-indazole monohydrochloride
  • 1-Benzyl-3-gamma-dimethylaminopropoxy-1H-indazole hydrochloride
  • 1-Propanamine, N,N-dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-, hydrochloride
  • 1-Propanamine, N,N-dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-, monohydrochloride
  • AF 864
  • AF-864
  • Benalgin
  • Benzidan
  • Benzydamine HCl
  • Benzydamine hydrochloride
  • Benzyrin
  • Difflam
  • Dorinamin
  • EINECS 205-076-0
  • Enzamin
  • Epirotin
  • Flogaton
  • Imotryl
  • Indolin
  • Multum
  • Oxinazin
  • Ririlim
  • Riripen
  • Salyzoron
  • Tamas
  • Tantum
  • UNII-K2GI407R4Q
  • Verax

Systematic Names

  • 1-Propanamine, N,N-dimethyl-3-((1-(phenylmethyl)-1H-indazol-3-yl)oxy)-, monohydrochloride
  • 1H-Indazole, 1-benzyl-3-(3-(dimethylamino)propoxy)-, monohydrochloride
  • 3-((1-Benzyl-1H-indazol-3-yl)oxy)-N,N-dimethylpropylamine monohydrochloride

Registry Numbers

CAS Registry Number

  • 132-69-4

FDA UNII

  • K2GI407R4Q

Related Registry Number

  • 642-72-8 (Parent)

System Generated Number

  • 0000132694

Molecular Formulas

Molecular Formula

  • C19-H23-N3-O.Cl-H

Molecular Formula Fragments

  • C19-H23-N3-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H23N3O.ClH/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16;/h3-7,9-12H,8,13-15H2,1-2H3;1H

InChIKey

HNNIWKQLJSNAEQ-UHFFFAOYSA-N

Smiles

Cl.c1(OCCCN(C)C)c2c(n(n1)Cc1ccccc1)cccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD intraperitoneal > 50mg/kg (50mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 10, Pg. 148, 1967.
child TDLo oral 50mg/kg (50mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Archiv fuer Toxikologie. Vol. 23, Pg. 215, 1968.
dog LD oral > 50mg/kg (50mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING
Toxicology and Applied Pharmacology. Vol. 10, Pg. 148, 1967.
mouse LD50 intraperitoneal 110mg/kg (110mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 10, Pg. 148, 1967.
mouse LD50 intravenous 33mg/kg (33mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 10, Pg. 148, 1967.
mouse LD50 oral 440mg/kg (440mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 1011, 1978.
mouse LD50 subcutaneous 218mg/kg (218mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Toxicology and Applied Pharmacology. Vol. 10, Pg. 148, 1967.
rabbit LD intravenous > 5mg/kg (5mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Toxicology and Applied Pharmacology. Vol. 10, Pg. 148, 1967.
rat LD50 intraperitoneal 72mg/kg (72mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 65, Pg. 620, 1969.
rat LD50 intravenous 43500ug/kg (43.5mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968.
rat LD50 oral 740mg/kg (740mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Yakugaku Zasshi. Journal of Pharmacy. Vol. 99, Pg. 240, 1979.
rat LD50 subcutaneous 720mg/kg (720mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 70, 1968.