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Substance Name: Chloroquine sulfate
RN: 132-73-0
UNII: OE48649K6N
InChIKey: OJPWHUOVKVKBQB-UHFFFAOYSA-N

Note

  • The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.

Molecular Formula

  • C18-H26-Cl-N3.H2-O4-S

Molecular Weight

  • 417.955
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
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Names and Synonyms

Results Name

  • Chloroquine sulfate

Name of Substance

  • Chloroquine sulfate

Synonyms

  • 1,4-Pentanediamine, N(sub 4)-(7-chloro-4-quinolinyl)-N(sub 1),N(sub 1)-diethyl-, sulfate
  • 7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline sulfate (1:1)
  • Chloroquin sulfate
  • Chloroquine sulfate
  • Chloroquine sulphate
  • Chlorquine sulfate
  • Cisplaquin
  • EINECS 205-077-6
  • Lariago
  • Melubrin
  • N(sub 4)-(7-Chloro-4-quinolinyl)-N(sub 1),N(sub 1)-diethyl-1,4-pentanediamine
  • Nivaquine
  • NSC 292296
  • RTECS VQ6580000
  • UNII-OE48649K6N

Systematic Names

  • 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, sulfate (1:1) (9CI)
  • Chloroquine sulphate
  • Quinoline, 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-, sulfate (1:1)

Registry Numbers

CAS Registry Number

  • 132-73-0

FDA UNII

  • OE48649K6N

System Generated Number

  • 0000132730

Molecular Formulas

Molecular Formula

  • C18-H26-Cl-N3.H2-O4-S

Molecular Formula Fragments

  • C18-H26-Cl-N3
  • COMPONENT
  • H2-O4-S

Structure Descriptors

InChI

1S/C18H26ClN3.H2O4S/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);(H2,1,2,3,4)

InChIKey

OJPWHUOVKVKBQB-UHFFFAOYSA-N

Smiles

N(CC)(CC)CCC[C@@H](Nc1ccnc2c1ccc(Cl)c2)C.S(=O)(=O)(O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women TDLo oral 120mg/kg (120mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: COMA

CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION
Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 23, 1991.
women TDLo oral 154mg/kg/11W- (154mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Archives of Dermatology. Vol. 121, Pg. 1164, 1985.