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Substance Name: Chlorthenoxazine [INN:BAN]
RN: 132-89-8
UNII: KA0B657LV3
InChIKey: YEKMWXFHPZBZLR-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C10-H10-Cl-N-O2

Molecular Weight

  • 211.647
 
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Names and Synonyms

Name of Substance

  • Chlorthenoxazin
  • Chlorthenoxazine [INN:BAN]

Synonyms

  • 2-(2-Chloroethyl)-2,3-dihydro-4-oxo-1,3-benzoxazine
  • 2-(2-Chloroethyl)-2,3-dihydro-4H-1,3-benzoxazin-4-one
  • 2-(2-Chloroethyl)-3-aza-4-chromanone
  • 2-(beta-Chloroethyl)-2,3-dihydro-4-oxo(benzo-1,3-oxazine)
  • 4-27-00-02766 (Beilstein Handbook Reference)
  • 4-Oxo-2-(beta-chloroethyl)-2,3-dihydrobenzo-1,3-oxazine
  • AP 67
  • Apirazin
  • Betix
  • BRN 0170863
  • Chlorethylbenzmethoxazone
  • Chlorthenoxazin
  • Chlorthenoxazine
  • Chlorthenoxazinum
  • Chlorthenoxazinum [INN-Latin]
  • Clortenoxazina
  • Clortenoxazina [INN-Spanish]
  • EINECS 205-082-3
  • NSC 525254
  • Ossazone
  • Ossipirina
  • Oxal
  • Reugaril
  • Reulin
  • Reumagrip
  • UNII-KA0B657LV3
  • Valmorin
  • Valtorin

Systematic Names

  • 2-(2-Chloroethyl)-2,3-dihydro-4H-1,3-benzoxazin-4-one
  • 4H-1,3-Benzoxazin-4-one, 2-(2-chloroethyl)-2,3-dihydro-
  • Chlorthenoxazine

Registry Numbers

CAS Registry Number

  • 132-89-8

FDA UNII

  • KA0B657LV3

System Generated Number

  • 0000132898

Structure Descriptors

InChI

1S/C10H10ClNO2/c11-6-5-9-12-10(13)7-3-1-2-4-8(7)14-9/h1-4,9H,5-6H2,(H,12,13)

InChIKey

YEKMWXFHPZBZLR-UHFFFAOYSA-N

Smiles

c12c(O[C@@H](CCCl)NC1=O)cccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1702mg/kg (1702mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 884, 1963.
mouse LD50 oral 11155mg/kg (11155mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 884, 1963.
rat LD50 intraperitoneal 730mg/kg (730mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
British Medical Journal. Vol. 1, Pg. 36, 1960.
rat LD50 oral 10gm/kg (10000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: COMA
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 651, 1957.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 146.5 dec deg C   EXP
log P (octanol-water) 2.390 (none)   EST
Atmospheric OH Rate Constant 8.56E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.