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Substance Name: Penicillin V potassium [USAN:USP]
RN: 132-98-9
UNII: 146T0TU1JB
InChIKey: HCTVWSOKIJULET-LQDWTQKMSA-M

Note

  • A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.

Molecular Formulas

  • C16-H17-K-N2-O5-S
  • C16-H17-N2-O5-S.K
  • C16-H18-N2-O5-S.K

Molecular Weight

  • 388.4833
 

Classification Codes

  • Antibacterial
  • Drug / Therapeutic Agent
  • Mutation Data
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Penicillin V potassium [USAN:USP]
  • Penicillin VK

Synonyms

  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(( phenoxyacetyl)amino)-, monopotassium salt, (2S-(2alpha,5alpha,6beta))-
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2 -phenoxyacetamido)-, monopotassium salt
  • Antibiocin
  • Apsin VK
  • Arcacil
  • Arcasin
  • Aspin VK
  • Beepen-VK
  • Beromycin
  • Beromycin (penicillin)
  • Betapen-VK
  • Calciopen K
  • CCRIS 750
  • Cliacil
  • Compocillin-VK
  • D-alpha-Phenoxymethylpenicillinate K salt
  • Distakaps V-K
  • Distaquaine V-K
  • Dov-k
  • Dowpen V-K
  • Dqv-K
  • EINECS 205-086-5
  • Fenoxypen
  • HSDB 6315
  • Icipen
  • Isocillin
  • Ispenoral
  • Kavepenin
  • Ledercillin VK
  • Megacillin oral
  • Monopotassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate
  • Oracil-VK
  • Orapen
  • Ospeneff
  • Pedipen
  • Pen VK
  • Pen-V-K powder
  • Pen-Vee K
  • Pen-Vee-K powder
  • Penagen
  • Penapar VK
  • Penapar-VK
  • Pencompren
  • Penicillin potassium phenoxymethyl
  • Penicillin V potassium
  • Penicillin V potassium salt
  • Penicillin VK
  • Penicillin-VK
  • Penvikal
  • Pfizerpen VK
  • Phenoxymethylpenicillin potassium
  • Potassium penicillin V
  • Potassium penicillin V salt
  • Potassium phenoxymethyl penicillin
  • Potassium phenoxymethylpenicillin
  • Primcillin
  • PVK
  • Qidpen VK
  • Robicillin VK
  • Rocillin-VK
  • Roscopenin
  • SK-Penicillin VK
  • Stabillin VK syrup 125
  • Stabillin VK syrup 62.5
  • Sumapen VK
  • Suspen
  • UNII-146T0TU1JB
  • Uticillin VK
  • V-Cil-K
  • V-Cillin K
  • Veetids
  • Veetids '125'
  • Veetids '250'
  • Veetids '500'
  • Vepen

Systematic Names

  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((2-phenoxyacetyl)amino)-, potassium salt (1:1), (2S,5R,6R)-
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-, monopotassium salt, (2S,5R,6R)-
  • Penicillin VK
  • Phenoxymethylpenicillin potassium

Superlist Name

  • Penicillin VK

Registry Numbers

CAS Registry Number

  • 132-98-9

FDA UNII

  • 146T0TU1JB

Other Registry Number

  • 8059-73-2

Related Registry Number

  • 87-08-1 (Parent)

System Generated Number

  • 0000132989

Molecular Formulas

Molecular Formulas

  • C16-H17-K-N2-O5-S
  • C16-H17-N2-O5-S.K
  • C16-H18-N2-O5-S.K

Molecular Formula Fragments

  • C16-H17-N2-O5-S
  • C16-H18-N2-O5-S
  • COMPONENT
  • K

Structure Descriptors

InChI

1S/C16H18N2O5S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)24-16)17-10(19)8-23-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1

InChIKey

HCTVWSOKIJULET-LQDWTQKMSA-M

Smiles

CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)COc3ccccc3)C(=O)[O-])C.[K+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1351mg/kg (1351mg/kg)   Drugs in Japan Vol. 6, Pg. 661, 1982.
mouse LD50 intravenous 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 751, 1962.
mouse LD50 oral > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 661, 1982.
mouse LD50 subcutaneous > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. 6, Pg. 661, 1982.
rat LD50 intramuscular 1124mg/kg (1124mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 29, Pg. 39, 1977.
rat LD50 intraperitoneal 1750mg/kg (1750mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 751, 1962.
rat LD50 oral > 1040mg/kg (1040mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.