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Substance Name: Cilnidipine [INN]
RN: 132203-70-4
UNII: 97T5AZ1JIP
InChIKey: KJEBULYHNRNJTE-DHZHZOJOSA-N

Note

  • Has excitatory & inhibitory action on the Ca+ channels in the rabbit basilar artery.

Molecular Formula

  • C27-H28-N2-O7

Molecular Weight

  • 492.5252
 

Classification Codes

  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Cilnidipine
  • Cilnidipine [INN]

Synonyms

  • Atelec
  • Cilnidipine
  • Cinalong
  • FRC 8653
  • FRC-8653
  • Siscard
  • UNII-97T5AZ1JIP

Systematic Names

  • (+-)-(E)-Cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-(+-)-

Registry Numbers

CAS Registry Number

  • 132203-70-4

FDA UNII

  • 97T5AZ1JIP

System Generated Number

  • 0132203704

Structure Descriptors

InChI

1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+

InChIKey

KJEBULYHNRNJTE-DHZHZOJOSA-N

Smiles

CC1=C(C(C(=C(N1)C)C(=O)OC/C=C/c2ccccc2)c3cccc(c3)[N+](=O)[O-])C(=O)OCCOC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse LD50 intraperitoneal 1845mg/kg (1845mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LIVER: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse LD50 oral > 5gm/kg (5000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat LD50 intraperitoneal 426mg/kg (426mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LIVER: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat LD50 oral 4412mg/kg (4412mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20(Suppl,