Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: FR 111142
RN: 132340-44-4
InChIKey: PBVLBMJXKARLBU-VWNABXHMSA-N

Note

  • An angiogenesis inhibitor produced by the fungus Scolecobasidium arenarium; an analog of fumagillol.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C22-H34-O7

Molecular Weight

  • 410.5036
 
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • FR 111142

Synonyms

  • FR-111142
  • WF 2015A

Systematic Names

  • 2-Hexenoic acid, 4,5-dihydroxy-, (3S,5S,6R)-5-methoxy-4-[2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester, (2E)-
  • 2-Hexenoic acid, 4,5-dihydroxy-, 5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)oxiranyl)-1-oxaspiro(2.5)oct-6-yl ester

Registry Numbers

CAS Registry Number

  • 132340-44-4

Other Registry Number

  • 123760-05-4

System Generated Number

  • 0132340444

Structure Descriptors

InChI

1S/C22H34O7/c1-13(2)6-8-17-21(4,29-17)20-19(26-5)16(10-11-22(20)12-27-22)28-18(25)9-7-15(24)14(3)23/h6-7,9,14-17,19-20,23-24H,8,10-12H2,1-5H3/b9-7+/t14?,15?,16-,17-,19-,20-,21+,22+/m1/s1

InChIKey

PBVLBMJXKARLBU-VWNABXHMSA-N

Smiles

CC(C(/C=C/C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)[C@@]3([C@H](O3)CC=C(C)C)C)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 1gm/kg (1000mg/kg)   Journal of Antibiotics. Vol. 45, Pg. 348, 1992.
mouse LD50 intravenous > 1gm/kg (1000mg/kg)   Journal of Antibiotics. Vol. 45, Pg. 348, 1992.