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Substance Name: Arsenic trioxide [USAN:JAN]
RN: 1327-53-3
UNII: S7V92P67HO
InChIKey: QTLQKAJBUDWPIB-UHFFFAOYSA-N

Note

  • NCI: A small-molecule arsenic compound with antineoplastic activity. The mechanism of action of arsenic trioxide is not completely understood. This agent causes damage to or degradation of the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein; induces apoptosis in acute promyelocytic leukemia (APL) cells and in many other tumor cell types; promotes cell differentiation and suppresses cell proliferation in many different tumor cell types; and is pro-angiogenic. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

Molecular Formula

  • As2-O3

Molecular Weight

  • 197.841
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Insecticide
  • Mutation Data
  • Out-Dated Pesticide
  • Reproductive Effect
  • Rodenticide
  • Treatment of Acute Promyelocytic Leukemia
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 224
  • 2011 CERCLA Priority List, Rank: 224
  • Known to be a Carcinogen
  • Reportable Quantity (RQ) = 1 lb
  • Threshold Planning Quantity (TPQ) = 100/10000 lb

Names and Synonyms

Name of Substance

  • Arsenic trioxide
  • Arsenic trioxide [USAN:JAN]

Synonyms

  • Acide arsenieux
  • Acide arsenieux [French]
  • AI3-01163
  • Anhydride arsenieux
  • Anhydride arsenieux [French]
  • Arseni trioxydum
  • Arsenic (III) oxide
  • Arsenic blanc
  • Arsenic blanc [French]
  • Arsenic oxide
  • Arsenic oxide (As2O3)
  • Arsenic sesquioxide
  • Arsenic trioxide
  • Arsenic(III) oxide
  • Arsenic(III) trioxide
  • Arsenicum album
  • Arsenigen saure
  • Arsenigen saure [German]
  • Arsenious acid
  • Arsenious Acid Anhydride
  • Arsenious oxide
  • Arsenious trioxide
  • Arsenite
  • Arsenolite
  • Arsenous acid
  • Arsenous acid anhydride
  • Arsenous anhydride
  • Arsenous oxide
  • Arsenous oxide anhydride
  • Arsenous oxide [ISO]
  • Arsenox
  • Arsentrioxide
  • Arsodent
  • Caswell No. 059
  • CCRIS 5455
  • Claudelite
  • Claudetite
  • Crude arsenic
  • Diarsenic trioxide
  • EC 215-481-4
  • EINECS 215-481-4
  • EPA Pesticide Chemical Code 007001
  • HSDB 419
  • Oxyde Arsenieux
  • Oxyde Arsenieux [ISO-French]
  • RCRA waste number P012
  • Trisenox
  • Trixenox
  • Trixonex
  • UN 1561
  • UNII-S7V92P67HO
  • White arsenic

Systematic Names

  • Arsenic oxide (As2O3)
  • Arsenic trioxide
  • Diarsenic trioxide

Superlist Names

  • Arsenic oxide
  • Arsenic oxide (As2O3)
  • Arsenic trioxide
  • Arsenic trioxide [UN1561] [Poison]
  • Arsenous oxide
  • RCRA waste no. P012
  • UN1561
  • White arsenic

Registry Numbers

CAS Registry Number

  • 1327-53-3

FDA UNII

  • S7V92P67HO

Other Registry Numbers

  • 28380-38-3
  • 856307-43-2

System Generated Number

  • 0001327533

Structure Descriptors

InChI

1S/2As.3O/q2*+3;3*-2

InChIKey

QTLQKAJBUDWPIB-UHFFFAOYSA-N

Smiles

[O-2].[O-2].[O-2].[As+3].[As+3]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cattle LDLo oral 30mg/kg (30mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1306, 1935.
chicken LDLo intradermal 13mg/kg (13mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1306, 1935.
dog LDLo intradermal 2mg/kg (2mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1306, 1935.
dog LDLo oral 10mg/kg (10mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1306, 1935.
human LDLo oral 1429ug/kg (1.429mg/kg)   Yakkyoku. Pharmacy. Vol. 31, Pg. 1247, 1980.
man LDLo oral 29mg/kg (29mg/kg) BEHAVIORAL: SLEEP

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: MUSCLE WEAKNESS
Annals of Emergency Medicine. Vol. 16, Pg. 702, 1987.
man LDLo oral 114mg/kg (114mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Human & Experimental Toxicology. Vol. 18, Pg. 640, 1999.
man LDLo oral 123mg/kg (123mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES

LIVER: OTHER CHANGES
Journal of Forensic Sciences. Vol. 36, Pg. 1163, 1992.
man LDLo oral 286mg/kg (286mg/kg) MUSCULOSKELETAL: OTHER CHANGES

LIVER: LIVER FUNCTION TESTS IMPAIRED

CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 45, 1991.
man LDLo oral 2857mg/kg (2857mg/kg) LIVER: FATTY LIVER DEGERATION

BEHAVIORAL: COMA

KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED
Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 131, 1991.
man LDLo unreported 2941ug/kg (2.941mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo oral 14857ug/kg (14.857mg/kg) BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"

SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Journal of Toxicology, Clinical Toxicology. Vol. 36, Pg. 27, 1998.
mouse LD50 intravenous 10700ug/kg (10.7mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 78, Pg. 392, 1951.
mouse LD50 oral 31500ug/kg (31.5mg/kg)   Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. Vol. 14, Pg. 86, 1980.
mouse LD50 subcutaneous 9800ug/kg (9.8mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 78, Pg. 392, 1951.
pigeon LDLo intradermal 100mg/kg (100mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1306, 1935.
rabbit LD50 oral 20190ug/kg (20.19mg/kg)   Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. Vol. 22, Pg. 284, 1988.
rabbit LDLo intravenous 10560ug/kg (10.56mg/kg) BLOOD: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Biochemische Zeitschrift. Vol. 70, Pg. 144, 1915.
rat LD50 intraperitoneal 871mg/kg (871mg/kg)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 19(3), Pg. 30, 1975.
rat LD50 oral 14600ug/kg (14.6mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 52(1), Pg. 21, 1987.
rat LDLo subcutaneous 8mg/kg (8mg/kg) SKIN AND APPENDAGES (SKIN): CORROSIVE: AFTER TOPICAL EXPOSURE Journal of Pharmacology and Experimental Therapeutics. Vol. 19, Pg. 337, 1922.
rat LDLo unreported 8mg/kg (8mg/kg)   Biochemische Zeitschrift. Vol. 184, Pg. 360, 1927.
women TDLo oral 20mg/kg (20mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: OTHER CHANGES
International Archives of Occupational and Environmental Health. Vol. 68, Pg. 342, 1996.
women TDLo oral 100mg/kg (100mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 471, 2000.
women TDLo oral 549mg/kg (549mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE

GASTROINTESTINAL: NAUSEA OR VOMITING
Japanese Journal of Acute Medicine. Vol. 20, Pg. 1557, 1996.