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Substance Name: Ramosetron hydrochloride
RN: 132907-72-3
UNII: 9551LHD87E
InChIKey: XIXYTCLDXQRHJO-RFVHGSKJSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C17-H17-N3-O.Cl-H

Molecular Weight

  • 315.8022
 
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Names and Synonyms

Results Name

  • Ramosetron hydrochloride

Name of Substance

  • Ramosetron hydrochloride
  • YM 060

Synonyms

  • (R)-5-((1-Methyl-3-indolyl)carbonyl)-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride
  • CCRIS 7704
  • Nasea
  • Ramosetron HCl
  • Ramosetron hydrochloride
  • UNII-9551LHD87E
  • YM-060
  • YM060

Systematic Names

  • Methanone, (1-methyl-1H-indol-3-yl)((5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-, monohydrochloride
  • Methanone, (1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-, monohydrochloride, (R)-

Registry Numbers

CAS Registry Number

  • 132907-72-3

FDA UNII

  • 9551LHD87E

System Generated Number

  • 0132907723

Molecular Formulas

Molecular Formula

  • C17-H17-N3-O.Cl-H

Molecular Formula Fragments

  • C17-H17-N3-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1

InChIKey

XIXYTCLDXQRHJO-RFVHGSKJSA-N

Smiles

Cn1cc(c2c1cccc2)C(=O)[C@@H]3CCc4c([nH]cn4)C3.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 30mg/kg (30mg/kg) SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 117, 1994.
dog LD oral > 60mg/kg (60mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 45, Pg. 760, 1995.
mouse LD50 intravenous 90mg/kg (90mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 652, 1996.
rat LD50 intravenous 151mg/kg (151mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 105, 1994.
rat LD50 oral 1264mg/kg (1264mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 41, Pg. 1048, 1999.