Skip Navigation
ChemIDplus A TOXNET DATABASE Lite•Browse•Advanced

Substance Name: Trichlormethiazide [USP:INN:JAN]
RN: 133-67-5
UNII: Q58C92TUN0
InChIKey: LMJSLTNSBFUCMU-UHFFFAOYSA-N

Note

  • A thiazide diuretic with properties similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)

Molecular Formula

  • C8-H8-Cl3-N3-O4-S2

Molecular Weight

  • 380.659
 

Classification Codes

  • Antihypertensive
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Diuretic
  • Diuretics
  • Drug / Therapeutic Agent
  • Human Data
  • Membrane Transport Modulators
  • Mutation Data
  • Natriuretic Agents
  • Sodium Chloride Symporter Inhibitors
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Regulatory Agencies (Superlist Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Trichlormethiazide
  • Trichlormethiazide [USP:INN:JAN]

MeSH Heading

  • Trichlormethiazide

Synonyms

  • (+-)-6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide, (+-)-
  • 3-Dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide
  • 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
  • 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide
  • 3-Dichloromethylhydrochlorothiazide
  • 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
  • 6-Chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide
  • Achletin
  • Anistadin
  • Aponorin
  • BRN 0629145
  • Carvacron
  • Chlopolidine
  • Ciba 7057-Su
  • Cretonin
  • Diu-Hydrin
  • Diurazida
  • Diurese
  • Diuroral
  • EINECS 205-118-8
  • Esmarin
  • Eurinol
  • Fluitran
  • Flurese
  • Flurese (VAN)
  • Flutra
  • Gangesol
  • HSDB 3406
  • Hydrotrichlorothiazide
  • Intromene
  • Isestran
  • Kubacron
  • Metahydrin
  • Nakva
  • Naqua
  • NSC 61560
  • Salurin (wadel)
  • Schebitran
  • Tachionin
  • Tolcasone
  • Trichlordiuride
  • Trichlorex
  • Trichlormas
  • Trichlormetazid
  • Trichlormethiazid
  • Trichlormethiazide
  • Trichlormethiazidum
  • Trichlormethiazidum [INN-Latin]
  • Trichloromethiadiazide
  • Trichloromethiazide
  • Triclordiuride
  • Triclormetiazida
  • Triclormetiazida [INN-Spanish]
  • Triclormetiazide
  • Triclormetiazide [DCIT]
  • Triclormetiazide [Italian]
  • Triflumen
  • UNII-Q58C92TUN0

Systematic Names

  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
  • Trichlormethiazide

Mixture Names

  • Metatensin
  • Naquasone (Veterinary)
  • Naquival

Registry Numbers

CAS Registry Number

  • 133-67-5

FDA UNII

  • Q58C92TUN0

Other Registry Number

  • 96782-89-7

System Generated Number

  • 0000133675

Structure Descriptors

InChI

1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)

InChIKey

LMJSLTNSBFUCMU-UHFFFAOYSA-N

Smiles

c12c(N[C@@H](C(Cl)Cl)NS2(=O)=O)cc(Cl)c(c1)S(N)(=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 3320ug/kg/7W- (3.32mg/kg) BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" Kyorin Igakkai Zasshi. Journal of the Kyorin Medical Society. Vol. 13, Pg. 199, 1982.
mouse LD50 intraperitoneal 540mg/kg (540mg/kg)   Farmaco, Edizione Scientifica. Vol. 16, Pg. 647, 1961.
mouse LD50 intravenous 750mg/kg (750mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 119, 1969.
mouse LD50 oral 2600mg/kg (2600mg/kg)   Farmaco, Edizione Scientifica. Vol. 16, Pg. 647, 1961.
rat LD50 intravenous 920mg/kg (920mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 119, 1969.
rat LD50 oral 5600mg/kg (5600mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 140, Pg. 249, 1963.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 270 dec deg C   EXP
log P (octanol-water) 0.62 (none)   EXP
Water Solubility 800 mg/L 25 EXP
Vapor Pressure 3.59E-11 mm Hg 25 EST
Henry's Law Constant 7.23E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 6.21E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.