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Substance Name: Trichlormethiazide [USP:INN:JAN]
RN: 133-67-5
UNII: Q58C92TUN0
InChIKey: LMJSLTNSBFUCMU-UHFFFAOYSA-N
Note
- A thiazide diuretic with properties similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830)
Molecular Formula
- C8-H8-Cl3-N3-O4-S2
Molecular Weight
- 380.659
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- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antihypertensive
- Antihypertensive Agents
- Cardiovascular Agents
- Diuretic
- Diuretics
- Drug / Therapeutic Agent
- Human Data
- Membrane Transport Modulators
- Mutation Data
- Natriuretic Agents
- Sodium Chloride Symporter Inhibitors
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Names and Synonyms
Name of Substance
- Trichlormethiazide
- Trichlormethiazide [USP:INN:JAN]
MeSH Heading
- Trichlormethiazide
Synonyms
- (+-)-6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide, (+-)-
- 3-Dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide
- 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
- 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide
- 3-Dichloromethylhydrochlorothiazide
- 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
- 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
- 6-Chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide
- Achletin
- Anistadin
- Aponorin
- BRN 0629145
- Carvacron
- Chlopolidine
- Ciba 7057-Su
- Cretonin
- Diu-Hydrin
- Diurazida
- Diurese
- Diuroral
- EINECS 205-118-8
- Esmarin
- Eurinol
- Fluitran
- Flurese
- Flurese (VAN)
- Flutra
- Gangesol
- HSDB 3406
- Hydrotrichlorothiazide
- Intromene
- Isestran
- Kubacron
- Metahydrin
- Nakva
- Naqua
- NSC 61560
- Salurin (wadel)
- Schebitran
- Tachionin
- Tolcasone
- Trichlordiuride
- Trichlorex
- Trichlormas
- Trichlormetazid
- Trichlormethiazid
- Trichlormethiazide
- Trichlormethiazidum
- Trichlormethiazidum [INN-Latin]
- Trichloromethiadiazide
- Trichloromethiazide
- Triclordiuride
- Triclormetiazida
- Triclormetiazida [INN-Spanish]
- Triclormetiazide
- Triclormetiazide [DCIT]
- Triclormetiazide [Italian]
- Triflumen
- UNII-Q58C92TUN0
Systematic Names
- 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
- Trichlormethiazide
Mixture Names
- Metatensin
- Naquasone (Veterinary)
- Naquival
Registry Numbers
CAS Registry Number
- 133-67-5
FDA UNII
- Q58C92TUN0
Other Registry Number
- 96782-89-7
System Generated Number
- 0000133675
Structure Descriptors
InChI
1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)InChIKey
LMJSLTNSBFUCMU-UHFFFAOYSA-NSmiles
c12c(N[C@@H](C(Cl)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 3320ug/kg/7W- (3.32mg/kg) | BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)" | Kyorin Igakkai Zasshi. Journal of the Kyorin Medical Society. Vol. 13, Pg. 199, 1982. |
mouse | LD50 | intraperitoneal | 540mg/kg (540mg/kg) | Farmaco, Edizione Scientifica. Vol. 16, Pg. 647, 1961. | |
mouse | LD50 | intravenous | 750mg/kg (750mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 119, 1969. | |
mouse | LD50 | oral | 2600mg/kg (2600mg/kg) | Farmaco, Edizione Scientifica. Vol. 16, Pg. 647, 1961. | |
rat | LD50 | intravenous | 920mg/kg (920mg/kg) | "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 119, 1969. | |
rat | LD50 | oral | 5600mg/kg (5600mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 140, Pg. 249, 1963. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 270 dec | deg C | EXP | |
log P (octanol-water) | 0.62 | (none) | EXP | |
Water Solubility | 800 | mg/L | 25 | EXP |
Vapor Pressure | 3.59E-11 | mm Hg | 25 | EST |
Henry's Law Constant | 7.23E-13 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 6.21E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.