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Substance Name: Tricresyl Phosphate (mixed isomers)
RN: 1330-78-5
UNII: 512641US16

Note

  • Synthetic high-temperature lubricating oil consisting of tri-o-cresyl phosphate 2%, tri-m-cresyl phosphate 42%, tri-p-cresyl phosphate 31%, tris(dimethylphenyl) phosphates 18%, tris(ethylphenyl) phosphate 6%, other triaryl phosphates 1%.

Molecular Formula

  • C21-H21-O4-P

Molecular Weight

  • 371.3906
 

Classification Codes

  • Human Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • TSCA Flag TP (Subject to the Proposed TSCA Section 4 Test Rule)
  • Tumor Data

Names and Synonyms

Results Name

  • Tricresyl Phosphate (mixed isomers)

Name of Substance

  • Imol S-140
  • Phosphoric acid, tris(methylphenyl) ester
  • TCP
  • Tricresyl phosphate
  • Tritolyl phosphate

Synonyms

  • AI3-16771
  • Caswell No. 884
  • CCRIS 5947
  • Celluflex 179C
  • Cresyl phosphate
  • Disflamoll TKP
  • Durad
  • EINECS 215-548-8
  • EPA Pesticide Chemical Code 083401
  • Flexol Plasticizer TCP
  • Fyrquel 150
  • HSDB 6774
  • IMOL S 140
  • Kronitex
  • Lindol
  • NCI-C61041
  • Phosflex 179A
  • Phosphate de tricresyle
  • Phosphate de tricresyle [French]
  • TCP
  • Thiorthocresyl phosphate
  • Tricresilfosfati
  • Tricresilfosfati [Italian]
  • Tricresyl phosphate
  • Tricresylfosfaten
  • Tricresylfosfaten [Dutch]
  • Trikresylfosfat
  • Trikresylfosfat [Czech]
  • Trikresylphosphate
  • Trikresylphosphate [German]
  • Tris(tolyloxy)phosphine oxide
  • Tritolyl phosphate
  • Tritolylfosfat
  • Tritolylfosfat [Czech]
  • UNII-512641US16

Systematic Names

  • Phosphoric acid, tris(methylphenyl) ester
  • Phosphoric acid, tritolyl ester
  • Reofos 65
  • Tricresyl phosphate
  • Tris(methylphenyl) phosphate

Superlist Names

  • Phosphoric acid, tritolyl ester
  • Tricresyl phosphate
  • Tricresyl phosphate with >3% ortho isomer
  • Tricresyl phosphate with >3% ortho isomer [UN2574] [Poison]
  • Tricresyl phosphate, <1% o-isomer
  • Tricresyl phosphate, >3% o-isomer
  • Tricresyl phosphate, not <1% o-isomer
  • Tritolyl phosphate, <1% o-isomer
  • Tritolyl phosphate, not <1% o-isomer
  • UN2574

Registry Numbers

CAS Registry Number

  • 1330-78-5

FDA UNII

  • 512641US16

Other Registry Numbers

  • 1259372-53-6
  • 2107376-26-9
  • 25013-17-6
  • 34902-62-0
  • 56499-45-7
  • 56573-10-5
  • 69234-04-4
  • 73299-28-2

System Generated Number

  • 0001330785

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 skin 1500mg/kg (1500mg/kg) BEHAVIORAL: ATAXIA

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Toxicology Letters. Vol. 1000(Sp,
chicken LD50 oral > 10gm/kg (10000mg/kg)   Toxicology and Applied Pharmacology. Vol. 41, Pg. 291, 1977.
dog LDLo oral 500mg/kg (500mg/kg)   "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968Vol. -, Pg. 339, 1968.
human LDLo oral 1800mg/kg (1800mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 585, 1957.
mouse LD50 oral 3900mg/kg (3900mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 114, 1982.
mouse LDLo subcutaneous 12mg/kg (12mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
"Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968Vol. -, Pg. 339, 1968.
rabbit LD50 parenteral 100mg/kg (100mg/kg)   International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.
rabbit LDLo oral 100mg/kg (100mg/kg)   "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968Vol. -, Pg. 339, 1968.
rabbit LDLo skin 1gm/kg (1000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
National Technical Information Service. Vol. OTS0534886,
rat LD50 oral 3gm/kg (3000mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 2, Pg. 96, 1975.
women TDLo oral 70mg/kg/14D (70mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Lancet. Vol. 1, Pg. 88, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -3.30E+01 deg C   EXP
Boiling Point 265 deg C   EXP
log P (octanol-water) 5.11 (none)   EXP
Water Solubility 0.36 mg/L 25 EXP
Henry's Law Constant 8.08E-07 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.44E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.