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Substance Name: Phenmetrazine [INN:BAN]
RN: 134-49-6
UNII: XA501VL3VR
InChIKey: OOBHFESNSZDWIU-UHFFFAOYSA-N

Note

  • A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to DEXTROAMPHETAMINE.

Molecular Formula

  • C11-H15-N-O

Molecular Weight

  • 177.2455
 

Classification Codes

Classification Codes

  • Anti-Obesity Agents
  • Appetite Depressants
  • Autonomic Agents
  • Central Nervous System Agents
  • Central Nervous System Stimulants
  • Human Data
  • Peripheral Nervous System Agents
  • Sympathomimetics

Superlist Classification Code

  • DEA Schedule II
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Names and Synonyms

Name of Substance

  • Dexphenmetrazine
  • Phenmetrazine
  • Phenmetrazine [INN:BAN]

MeSH Heading

  • Phenmetrazine

Synonyms

  • 2-Fenyl-3-methylmorfolin
  • 2-Fenyl-3-methylmorfolin [Czech]
  • 2-Phenyl-3-methylmorpholine
  • 3-Methyl-2-phenylmorpholine
  • 3-Methyl-2-phenyltetrahydro-2H-1,4-oxazine
  • 4-27-00-01050 (Beilstein Handbook Reference)
  • A 66
  • BRN 0140490
  • dl-2-Phenyl-3-methyltetrahydro-1,4-oxazine
  • EINECS 205-143-4
  • Fenmetrazina
  • Fenmetrazina [INN-Spanish]
  • HSDB 3156
  • Morpholine, 3-methyl-2-phenyl-
  • Oxazimedrine
  • Phenmetrazin
  • Phenmetrazine
  • Phenmetrazinum
  • Phenmetrazinum [INN-Latin]
  • Preludin
  • Probese-P
  • Psychamine A 66
  • UNII-XA501VL3VR

Systematic Names

  • Morpholine, 3-methyl-2-phenyl-
  • Phenmetrazine

Superlist Names

  • DEA No. 1631
  • Phenmetrazine

Registry Numbers

CAS Registry Number

  • 134-49-6

FDA UNII

  • XA501VL3VR

Other Registry Numbers

  • 154-40-5
  • 21288-73-3

Related Registry Number

  • 1707-14-8 (hydrochloride)

System Generated Number

  • 0000134496

Structure Descriptors

InChI

1S/C11H15NO/c1-9-11(13-8-7-12-9)10-5-3-2-4-6-10/h2-6,9,11-12H,7-8H2,1H3

InChIKey

OOBHFESNSZDWIU-UHFFFAOYSA-N

Smiles

CC1NCCOC1c2ccccc2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 2857ug/kg (2.857mg/kg) AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC Therapie. Vol. 34, Pg. 205, 1979.
mouse LD50 intraperitoneal 125mg/kg (125mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: IRRITABILITY

BEHAVIORAL: EXCITEMENT
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 1727, 1971.
mouse LD50 oral 125mg/kg (125mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 810, 1973.
mouse LD50 subcutaneous 195mg/kg (195mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 222, Pg. 540, 1954.
rat LD50 oral 370mg/kg (370mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 810, 1973.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 1.490 (none)   EST
Atmospheric OH Rate Constant 1.42E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.