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Substance Name: Amprotropine phosphate
RN: 134-53-2
UNII: 6831EK981Y
InChIKey: YHASIXBUOZWGHL-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H29-N-O3.H3-O4-P

Molecular Weight

  • 405.425
 
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Names and Synonyms

Name of Substance

  • Amprotropine phosphate

Synonyms

  • 1-Propanol, 3-(diethylamino)-2,2-dimethyl-, tropate, phosphate
  • 3-Diethylamino-2,2-dimethylpropyl tropate phospate
  • Amprotropine phosphate
  • AP 407
  • d,l-Tropasaeureester des 3-diaethylamino-2,2-dimethyl-1-propanol phosphat
  • d,l-Tropasaeureester des 3-diaethylamino-2,2-dimethyl-1-propanol phosphat [German]
  • Syntropan
  • UNII-6831EK981Y

Systematic Name

  • Tropic acid, 3-(diethylamino)-2,2-dimethylpropyl ester, phosphate (1:1)

Registry Numbers

CAS Registry Number

  • 134-53-2

FDA UNII

  • 6831EK981Y

Related Registry Number

  • 148-32-3 (Parent)

System Generated Number

  • 0000134532

Molecular Formulas

Molecular Formula

  • C18-H29-N-O3.H3-O4-P

Molecular Formula Fragments

  • C18-H29-N-O3
  • COMPONENT
  • H3-O4-P

Structure Descriptors

InChI

1S/C18H29NO3.H3O4P/c1-5-19(6-2)13-18(3,4)14-22-17(21)16(12-20)15-10-8-7-9-11-15;1-5(2,3)4/h7-11,16,20H,5-6,12-14H2,1-4H3;(H3,1,2,3,4)

InChIKey

YHASIXBUOZWGHL-UHFFFAOYSA-N

Smiles

c1([C@@H](C(OCC(CN(CC)CC)(C)C)=O)CO)ccccc1.P(O)(O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo subcutaneous 200mg/kg (200mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 1, 1937.
frog LDLo parenteral 1gm/kg (1000mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 173, Pg. 86, 1933.
frog LDLo subcutaneous 1500mg/kg (1500mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 1, 1937.
mouse LD50 intravenous 51mg/kg (51mg/kg)   Journal of Laboratory and Clinical Medicine. Vol. 30, Pg. 700, 1945.
mouse LDLo oral 570mg/kg (570mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 1, 1937.
mouse LDLo subcutaneous 1250mg/kg (1250mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 1, 1937.
rabbit LD50 intravenous 25mg/kg (25mg/kg)   Schweizerische Medizinische Wochenschrift. Vol. 76, Pg. 1282, 1946.
rabbit LDLo subcutaneous 500mg/kg (500mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 1, 1937.
rat LD50 intravenous 43mg/kg (43mg/kg)   Journal of Laboratory and Clinical Medicine. Vol. 30, Pg. 700, 1945.