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Substance Name: Ephedrine sulfate [USP]
RN: 134-72-5
UNII: U6X61U5ZEG
InChIKey: CAVQBDOACNULDN-KHFUBBAMSA-N
Note
- A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
Molecular Formulas
- C10-H15-N-O.1/2H2-O4-S
- C20-H30-N2-O2.H2-O4-S
Molecular Weight
- 428.5468
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Adrenergic
- Adrenergic Agents
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Tumor Data
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Names and Synonyms
Name of Substance
- Ephedrine l- sulfate
- Ephedrine sulfate [USP]
Synonyms
- (-)-Ephedrine sulfate (2:1) (salt)
- (-)-erythro-1-Hydroxy-2-(methylamino)-1-phenylpropane sulfate
- (1R,2S)-1-Phenyl-2-methylaminopropanol-1 sulfate
- 1-alpha-(1-(Methylamino)ethyl)benzyl alcohol sulfate
- 1-Phenyl-2-methylamine-propanol-1-sulfate
- Akovaz
- Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (R-(R*,S*))-, sulfate (2:1) (salt)
- CCRIS 1351
- EC 205-154-4
- EINECS 205-154-4
- Ephedrine sulfate
- Ephedrine sulphate
- Isofedrol
- l-Ephedrine sulfate
- NCI-C55652
- UNII-U6X61U5ZEG
Systematic Names
- Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alphaR)-, sulfate (2:1)
- Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alphaR)-, sulfate (2:1) (salt)
- Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (R-(R*,S*))-, sulfate (2:1) (salt)
- Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (theta-(theta,S))-, sulfate (2:1) (salt)
- Bis((R-(R*,S*))-beta-hydroxy-alpha-methylphenethyl)methylammonium sulphate
- Bis((R-(R*,S*))-beta-hydroxy-alpha-methylphenethyl)methylammonium) sulphate
- Ephedrine sulfate
- Ephedrine sulfate (2:1) (salt), (-)-
Superlist Name
- Ephedrine sulfate
Mixture Names
- Bronkaid Caplets
- Pazo Ointment
- Pazo Suppositories
Registry Numbers
CAS Registry Number
- 134-72-5
FDA UNII
- U6X61U5ZEG
Other Registry Numbers
- 17140-50-0
- 33096-52-5
- 8048-37-1
- 8052-22-0
- 909278-77-9
- 95330-22-6
System Generated Number
- 0000134725
Molecular Formulas
Molecular Formulas
- C10-H15-N-O.1/2H2-O4-S
- C20-H30-N2-O2.H2-O4-S
Molecular Formula Fragments
- C10-H15-N-O
- C20-H30-N2-O2
- COMPONENT
- H2-O4-S
Structure Descriptors
InChI
1S/2C10H15NO.H2O4S/c2*1-8(11-2)10(12)9-6-4-3-5-7-9;1-5(2,3)4/h2*3-8,10-12H,1-2H3;(H2,1,2,3,4)/t2*8-,10-;/m00./s1InChIKey
CAVQBDOACNULDN-KHFUBBAMSA-NSmiles
CN[C@@H](C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LDLo | intravenous | 75mg/kg (75mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Journal of Pharmacology and Experimental Therapeutics. Vol. 27, Pg. 61, 1926. |
dog | LDLo | intravenous | 70mg/kg (70mg/kg) | BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Journal of Pharmacology and Experimental Therapeutics. Vol. 27, Pg. 61, 1926. |
frog | LDLo | parenteral | 530mg/kg (530mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE WEAKNESS | Journal of Pharmacology and Experimental Therapeutics. Vol. 27, Pg. 61, 1926. |
guinea pig | LDLo | subcutaneous | 425mg/kg (425mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 27, Pg. 61, 1926. |
human | TDLo | intravenous | 1mg/kg (1mg/kg) | VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 120, Pg. 189, 1927. |
mouse | LD50 | intraperitoneal | 270mg/kg (270mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: STRAUB TAIL SKIN AND APPENDAGES (SKIN): HAIR: OTHER | Toxicology and Applied Pharmacology. Vol. 15, Pg. 304, 1969. |
mouse | LD50 | oral | 812mg/kg (812mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION | National Toxicology Program Technical Report Series. Vol. NTP-TR-307, Pg. 1986, |
rabbit | LD50 | intravenous | 73mg/kg (73mg/kg) | PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 150, 1948. |
rabbit | LD50 | oral | 825mg/kg (825mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 150, 1948. |
rabbit | LD50 | subcutaneous | 383mg/kg (383mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 150, 1948. |
rabbit | LDLo | intramuscular | 340mg/kg (340mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Journal of Pharmacology and Experimental Therapeutics. Vol. 27, Pg. 61, 1926. |
rabbit | LDLo | intraperitoneal | 310mg/kg (310mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: TREMOR | Journal of Pharmacology and Experimental Therapeutics. Vol. 27, Pg. 61, 1926. |
rat | LD50 | intravenous | 102mg/kg (102mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 150, 1948. |
rat | LD50 | oral | 404mg/kg (404mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 150, 1948. |
rat | LD50 | subcutaneous | 318mg/kg (318mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 150, 1948. |