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Substance Name: Diethylpropion hydrochloride [USP]
RN: 134-80-5
UNII: 19V2PL39NG
InChIKey: ICFXZZFWRWNZMA-UHFFFAOYSA-N

Note

  • A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)

Molecular Formula

  • C13-H19-N-O.Cl-H

Molecular Weight

  • 241.76
 

Classification Codes

Classification Codes

  • Anorexic
  • Drug / Therapeutic Agent

Superlist Classification Code

  • DEA Schedule IV
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Names and Synonyms

Name of Substance

  • Diethylpropion hydrochloride [USP]

Synonyms

  • 1-Phenyl-2-diethylaminopropanone-1 hydrochloride
  • 1-Propanone, 2-(diethylamino)-1-phenyl-, hydrochloride
  • 2-(Diethylamino)propiophenone hydrochloride
  • alpha-Benzoyltriethylamine hydrochloride
  • alpha-Benzoyltriethylammonium chloride
  • Amfepramon hydrochloride
  • Amphepramonum hydrochloride
  • Diethylpropion
  • Diethylpropion HCl
  • Diethylpropion hydrochloride
  • Dobesin
  • EINECS 205-156-5
  • Lineal-Rivo
  • Magrex Retard
  • Menutil
  • Moderatan
  • Nu-Dispoz
  • Regenon hydrochloride
  • Tenuate
  • Tenuate Dospan
  • Tenuate-Dospan
  • Tepanil
  • Tepanil Ten-Tab
  • UNII-19V2PL39NG

Systematic Names

  • 1-Propanone, 2-(diethylamino)-1-phenyl-, hydrochloride
  • Amfepramone hydrochloride
  • Propiophenone, 2-(diethylamino)-, hydrochloride

Superlist Names

  • DEA No. 1610
  • Tenuate
  • Tepanil

Registry Numbers

CAS Registry Number

  • 134-80-5

FDA UNII

  • 19V2PL39NG

System Generated Number

  • 0000134805

Molecular Formulas

Molecular Formula

  • C13-H19-N-O.Cl-H

Molecular Formula Fragments

  • C13-H19-N-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C13H19NO.ClH/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12;/h6-11H,4-5H2,1-3H3;1H

InChIKey

ICFXZZFWRWNZMA-UHFFFAOYSA-N

Smiles

CCN(CC)C(C)C(=O)c1ccccc1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 160mg/kg (160mg/kg)   Therapie. Vol. 17, Pg. 373, 1962.
mouse LD50 intravenous 50mg/kg (50mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 17, Pg. 182, 1960.
mouse LD50 oral 385mg/kg (385mg/kg)   Therapie. Vol. 17, Pg. 373, 1962.
mouse LD50 subcutaneous 450mg/kg (450mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: EXCITEMENT
Acta Pharmaceutica Suecica. Vol. 4, Pg. 37, 1967.
rat LD50 intraperitoneal 139mg/kg (139mg/kg) BEHAVIORAL: EXCITEMENT Acta Pharmacologica et Toxicologica. Vol. 17, Pg. 121, 1960.
rat LD50 oral 400mg/kg (400mg/kg)   Therapie. Vol. 17, Pg. 373, 1962.