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Substance Name: Nartograstim [INN:JAN]
RN: 134088-74-7
UNII: H8FKD75R37

Note

  • A mutein of recombinant human G-CSF.

Molecular Formula

  • C850-H1344-N226-O245-S8

Molecular Weight

  • 18905.8326
 

Classification Codes

  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Natural Product
  • Reproductive Effect
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Links to Resources

Names and Synonyms

Name of Substance

  • Nartograstim
  • Nartograstim [INN:JAN]

Synonyms

  • KW-2228
  • Marograstim
  • Nartograstim
  • UNII-H8FKD75R37

Systematic Names

  • Colony-stimulating factor (human clone 1034), 1-(N-L-methionyl-L-alanine)-3-L-threonine-4-L-tyrosine-5-L-arginine-17-L-serine-
  • N-L-Methionyl-1-L-alanine-3-L-threonine-4-L-tyrosine-5-L-arginine-17-L-serinecolony-stimulating factor (human clone 1034)

Registry Numbers

CAS Registry Number

  • 134088-74-7

FDA UNII

  • H8FKD75R37

System Generated Number

  • 0134088747

Structure Descriptors

Smiles

CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CCCN5C(=O)[C@H](C)NC(=O)[C@H](Cc6c[nH]c7ccccc67)NC(=O)[C@@H]8CCCN8C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc9cnc[nH]9)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]%10CCCN%10C(=O)[C@H](Cc%11cnc[nH]%11)NC(=O)[C@@H]%12CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc%13ccccc%13)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]%14CCCN%14C(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc%15ccc(O)cc%15)NC(=O)[C@@H](NC(=O)[C@@H]%16CCCN%16C(=O)[C@H](C)NC(=O)[C@@H](N)CCSC)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc%17ccc(O)cc%17)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N%12)C(C)C)[C@@H](C)CC)C(=O)N%18CCC[C@H]%18C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N4)C(=O)N[C@@H](CO)C(=O)N%19CCC[C@H]%19C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N%20CCC[C@H]%20C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc%21ccccc%21)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc%22c[nH]c%23ccccc%22%23)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N%24CCC[C@H]%24C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N%25CCC[C@H]%25C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N%26CCC[C@H]%26C(=O)N[C@@H](C)C(=O)N[C@@H](Cc%27ccccc%27)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc%28ccccc%28)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc%29cnc[nH]%29)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc%30ccccc%30)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc%31ccc(O)cc%31)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc%32cnc[nH]%32)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N%33CCC[C@H]%33C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD intravenous > 3mg/kg (3mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 41, Pg. 315, 1991.
monkey LD subcutaneous > 3mg/kg (3mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 41, Pg. 315, 1991.
rat LD intravenous > 3470ug/kg (3.47mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 41, Pg. 307, 1991.
rat LD subcutaneous > 3470ug/kg (3.47mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 41, Pg. 307, 1991.