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Substance Name: Krestin
RN: 134192-05-5
UNII: 3X48A86C8K

Note

  • Protein-bound polysaccharide preparation from Coriolus versicolor(Fr) Quel of Basidiomycetes with antitumor activity; immunopotentiator.

Molecular Formula

  • Unspecified

Molecular Weight

  • 971.8321
 

Classification Codes

  • Adjuvants, Immunologic
  • Anti-Infective Agents
  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Antiviral Agents
  • Immunologic Factors
  • Interferon Inducers
  • Protective Agents
  • Radiation-Protective Agents
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Links to Resources

Names and Synonyms

Results Name

  • Krestin

Name of Substance

  • Polysaccharide-K

Synonyms

  • CCRIS 7515
  • Crestine
  • Glycoproteins (specific proteins and subclasses), PS-K
  • Glycoproteins PSK
  • Polysaccharide krestin
  • PS-K
  • PSK
  • UNII-3X48A86C8K

Systematic Names

  • Glycoproteins, specific or class, PS-K
  • Krestin

Registry Numbers

CAS Registry Number

  • 134192-05-5

FDA UNII

  • 3X48A86C8K

System Generated Number

  • 0134192055

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. 6, Pg. 230, 1982.
monkey LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. 6, Pg. 230, 1982.
mouse LD50 intraperitoneal > 5gm/kg (5000mg/kg)   Merck Index. Vol. 11, Pg. 1261, 1989.
mouse LD50 intravenous 700mg/kg (700mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 1, Pg. 62, 1980.
mouse LD50 oral > 20gm/kg (20000mg/kg)   Drugs in Japan Vol. -, Pg. 397, 1995.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Japan Medical Gazette. Vol. 13(9), Pg. 11, 1976.
rat LD50 intraperitoneal > 5gm/kg (5000mg/kg)   Japan Medical Gazette. Vol. 13(9), Pg. 11, 1976.
rat LD50 intravenous > 600mg/kg (600mg/kg)   Japan Medical Gazette. Vol. 13(9), Pg. 11, 1976.
rat LD50 oral > 20gm/kg (20000mg/kg)   Merck Index. Vol. 11, Pg. 1261, 1989.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Japan Medical Gazette. Vol. 13(9), Pg. 11, 1976.