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Substance Name: Pyrithione zinc [USAN:INN]
RN: 13463-41-7
UNII: R953O2RHZ5
InChIKey: YLKVGIAZVBMIRR-UHFFFAOYSA-M

Note

  • Dimer of two pyrithione molecules bound by zinc; ingredient of commercial anti-dandruff shampoos; antifungal and antibacterial.

Molecular Formula

  • C10-H8-N2-O2-S2-Zn

Molecular Weight

  • 320.7309
 

Classification Codes

  • Antibacterial
  • Antifungal
  • Antiseborrheic
  • Dermatologic Agents
  • Keratolytic Agents
  • Reproductive Effect
  • Skin / Eye Irritant
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Names and Synonyms

Name of Substance

  • Bis(1-hydroxy-2(1H)-pyridinethionato)zinc
  • Pyrithione zinc
  • Pyrithione zinc [USAN:INN]
  • Zinc bis(2-pyridylthio)-N-oxide
  • Zinc pyrithione
  • Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-

Synonyms

  • 2(1H)-Pyridinethione, 1-hydroxy-, zinc complex
  • 2-Mercaptopyridine 1-oxide zinc salt
  • 2-Pyridinethiol-1-oxide, zinc salt
  • AI3-62421
  • BC-J
  • Biocut ZP
  • Bis(1-hydroxy-2(1H)-pyridinethionato)zinc
  • Bis(2-pyridinethiol-1-oxide)zinc
  • Bis(2-pyridylthio)zinc 1,1'-dioxide
  • Breck One Dandruff Shampoo
  • Caswell No. 923
  • CCRIS 4894
  • EC 236-671-3
  • EINECS 236-671-3
  • EPA Pesticide Chemical Code 088002
  • Evafine P 50
  • Finecide ZPT
  • FSB 8332
  • Head & Shoulders Conditioner
  • Head and Shoulders
  • Hokucide ZPT
  • HSDB 4498
  • Niccanon SKT
  • NSC 290409
  • OM-1563
  • Omadine Zinc
  • Piritionato cincico
  • Piritionato cincico [INN-Spanish]
  • Pyrithione zinc
  • Pyrithione zincique
  • Pyrithione zincique [INN-French]
  • Pyrithionum zincicum
  • Pyrithionum zincicum [INN-Latin]
  • Sebulon Shampoo
  • Tomicide Z 50
  • Tomicide ZPT 50
  • Top Brass
  • UNII-R953O2RHZ5
  • Vancide P
  • Vancide ZP
  • Wella Crisan
  • Zinc - pyrion
  • Zinc 1-hydroxy-2-pyridinethione
  • Zinc 2-mercaptopyridine N-oxide
  • Zinc Omadine
  • Zinc PT
  • Zinc pyrethion
  • Zinc pyridine-2-thiol 1-oxide
  • Zinc pyridine-2-thiol-1-oxide
  • Zinc pyridinethione
  • Zinc pyrithione
  • Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-
  • Zinc, bis(2-pyridinylthio)-, N,N'-dioxide
  • Zinc, bis(2-pyridylthio)-, 1,1'-dioxide
  • Zinc, bis(2-pyridylthio)-, N,N'-dioxide
  • Zinci pyrithionum
  • Zincon Dandruff Shampoo
  • Zincopan
  • Zincpolyanemine
  • Zn - pyrion
  • ZNP Bar
  • ZnPT
  • ZPT

Systematic Names

  • (T-4)-Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc
  • Pyrithione zinc
  • Zinc pyrithione
  • Zinc, bis(1-(hydroxy-kappaO)-2(1H)-pyridinethionato-kappaS2)-, (T-4)-
  • Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)- (8CI)
  • Zinc, bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-(T-4)-
  • Zinc, bis(2-pyridylthio)-, N,N'-dioxide

Superlist Names

  • Zinc 2-pyridinethiol-1-oxide
  • Zinc pyrithione
  • Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-

Registry Numbers

CAS Registry Number

  • 13463-41-7

FDA UNII

  • R953O2RHZ5

Other Registry Numbers

  • 1021487-49-9
  • 109702-19-4
  • 118480-78-7
  • 1192-70-7
  • 1199553-62-2
  • 1320-68-9
  • 1323439-04-8
  • 14376-32-0
  • 15686-64-3
  • 162400-43-3
  • 16782-00-6
  • 17652-47-0
  • 186322-74-7
  • 192458-89-2
  • 208398-70-3
  • 226883-65-4
  • 244778-79-8
  • 266692-38-0
  • 31089-48-2
  • 3138-01-0
  • 318995-78-7
  • 35430-20-7
  • 3590-23-6
  • 3865-77-8
  • 39412-61-8
  • 51148-10-8
  • 51406-57-6
  • 55172-61-7
  • 74261-71-5
  • 943428-71-5

System Generated Number

  • 0013463417

Structure Descriptors

InChI

1S/C5H6NOS.C5H4NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h1-5,8H;1-4H;/q2*-1;+3/p-1

InChIKey

YLKVGIAZVBMIRR-UHFFFAOYSA-M

Smiles

C1=CC2S=[Zn+2]3(S=C4C=CC=CN4[O-]3)[O-]N2C=C1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 600mg/kg (600mg/kg)   Clinical Toxicology. Vol. 13, Pg. 1, 1978.
dog LDLo intravenous 25mg/kg (25mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
Toxicology and Applied Pharmacology. Vol. 9, Pg. 269, 1966.
guinea pig LD50 oral > 2gm/kg (2000mg/kg)   Toxicology and Applied Pharmacology. Vol. 7, Pg. 425, 1965.
mammal (species unspecified) LC50 inhalation 140mg/m3/4H (140mg/m3)   United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-0790-1035,
monkey LDLo intravenous 25mg/kg (25mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Toxicology and Applied Pharmacology. Vol. 9, Pg. 269, 1966.
mouse LD50 intraperitoneal 26800ug/kg (26.8mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1067, 1974.
mouse LD50 oral 160mg/kg (160mg/kg)   Clinical Toxicology. Vol. 13, Pg. 1, 1978.
mouse LD50 subcutaneous 730mg/kg (730mg/kg)   Clinical Toxicology. Vol. 13, Pg. 1, 1978.
rabbit LD50 skin 100mg/kg (100mg/kg)   Yakkyoku. Pharmacy. Vol. 32, Pg. 965, 1981.
rabbit LDLo intravenous 10mg/kg (10mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Toxicology and Applied Pharmacology. Vol. 9, Pg. 269, 1966.
rat LC50 inhalation 140mg/m3/4H (140mg/m3) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
National Technical Information Service. Vol. OTS0527753-1,
rat LD50 oral 177mg/kg (177mg/kg)   Toxicology Annual. Vol. 3, Pg. 1, 1979.