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Substance Name: Pargeverine [INN]
RN: 13479-13-5
UNII: UC61HM8FX0
InChIKey: QNPHCSSJLHAKSA-UHFFFAOYSA-N

Note

  • Used as premedication when performing endoscopic retrograde cholangiopancreatography (ERCP).

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H23-N-O3

Molecular Weight

  • 337.417
 
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Names and Synonyms

Name of Substance

  • Pargeverine [INN]
  • Propinox

Synonyms

  • BE 50
  • Benzeneacetic acid, alpha-phenyl-alpha-(2-propynyloxy)-, 2-(dimethylamino)ethyl ester
  • BRN 2226014
  • Diphenyl(2-propynyloxy)acetic acid 2-(dimethylamino)ethyl ester
  • Pargeverina
  • Pargeverina [INN-Spanish]
  • Pargeverine
  • Pargeverinum
  • Pargeverinum [INN-Latin]
  • Propinox
  • Terisal
  • UNII-UC61HM8FX0

Systematic Names

  • 2-(Dimethylamino)ethyl diphenyl(2-propynyloxy)acetate
  • Acetic acid, diphenyl(2-propynyloxy)-, 2-(dimethylamino)ethyl ester
  • Benzeneacetic acid, alpha-phenyl-alpha-(2-propynyloxy)-, 2-(dimethylamino)ethyl ester

Registry Numbers

CAS Registry Number

  • 13479-13-5

FDA UNII

  • UC61HM8FX0

System Generated Number

  • 0013479135

Structure Descriptors

InChI

1S/C21H23NO3/c1-4-16-25-21(18-11-7-5-8-12-18,19-13-9-6-10-14-19)20(23)24-17-15-22(2)3/h1,5-14H,15-17H2,2-3H3

InChIKey

QNPHCSSJLHAKSA-UHFFFAOYSA-N

Smiles

C(c1ccccc1)(c1ccccc1)(C(OCCN(C)C)=O)OCC#C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 subcutaneous 240mg/kg (240mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: EXCITEMENT
Acta Biologica et Medica Germanica. Vol. 10, Pg. 357, 1963.