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Substance Name: GE 2270 A
RN: 134861-34-0
UNII: JB4J58L2K1
InChIKey: JMDULECOHIXMNX-MZHFYNGJSA-N

Note

  • From Planobispora rosea; inhibits bacterial protein synthesis in vitro by affecting specifically the GTP-bound form of elongation factor Tu.

Molecular Formula

  • C56-H55-N15-O10-S6

Molecular Weight

  • 1290.5415
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
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Names and Synonyms

Name of Substance

  • GE 2270 A

Synonyms

  • 2-(4-(4-((2-(Aminocarbonyl)-1-pyrrolidinyl)carbonyl)-4,5-dihydro-2-oxazolyl)-2-thiazolyl)-10,11,17,18,23,24,25,26,27,28-decahydro-28-(hydroxyphenylmethyl)-14-(methoxymethyl)-N,21-dimethyl-11-(1-methylethyl)-9,16,23,26-tetraoxo-9H,16H-8,5:15,12:22,19:32,29:36,33-pentanitrilo-5H,29H,33H-pyrido(3,2-a1)(1,11,18,25,31,4,7,14,21)pentathiatetraazacyclotetratriacontine-18-acetamide
  • Antibiotic GE 2270A
  • GE 2770
  • GE-2270
  • GE-2270A
  • Mdl 62879
  • UNII-JB4J58L2K1

Systematic Name

  • 9H,16H-8,5:15,12:22,19:32,29:36,33-Pentanitrilo-5H,29H,33H-pyrido(3,2-a1)(1,11,18,25,31,4,7,14,21)pentathiatetraazacyclotetratriacontine-18-acetamide, 2-(4-(4-((2-(aminocarbonyl)-1-pyrrolidinyl)carbonyl)-4,5-dihydro-2-oxazolyl)-2-thiazolyl)-10,11,17,18,23,24,25,26,27,28-decahydro-28-(hydroxyphenylmethyl)-14-(methoxymethyl)-N,21-dimethyl-11-(1-methylethyl)-9,16,23,26-tetraoxo-

Registry Numbers

CAS Registry Number

  • 134861-34-0

FDA UNII

  • JB4J58L2K1

Other Registry Numbers

  • 135526-68-0
  • 169059-69-2

System Generated Number

  • 0134861340

Structure Descriptors

InChI

1S/C56H55N15O10S6/c1-24(2)39-55-70-42(36(87-55)19-80-5)47(77)59-17-38(73)67-43(44(74)26-10-7-6-8-11-26)54-66-34(23-85-54)52-63-31(20-83-52)41-27(50-64-32(21-82-50)46(76)61-29(16-37(72)58-4)53-69-40(25(3)86-53)48(78)68-39)13-14-28(60-41)51-65-33(22-84-51)49-62-30(18-81-49)56(79)71-15-9-12-35(71)45(57)75/h6-8,10-11,13-14,20-24,29-30,35,39,43-44,74H,9,12,15-19H2,1-5H3,(H2,57,75)(H,58,72)(H,59,77)(H,61,76)(H,67,73)(H,68,78)/t29-,30-,35-,39-,43-,44-/m0/s1

InChIKey

JMDULECOHIXMNX-MZHFYNGJSA-N

Smiles

CNC(=O)C[C@@H]1NC(=O)c2csc(n2)c3ccc(nc3c4csc(n4)c5csc(n5)[C@@H](NC(=O)CNC(=O)c6nc(sc6COC)[C@@H](NC(=O)c7nc1sc7C)C(C)C)[C@@H](O)c8ccccc8)c9nc(cs9)C%10=N[C@@H](CO%10)C(=O)N%11CCC[C@H]%11C(=O)N