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Substance Name: Retinoic acid, all-trans-, sodium salt
RN: 13497-05-7
InChIKey: MLZFHHXDDHGSIR-ABAXVIISSA-M

Note

  • An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).

Molecular Formula

  • C20-H27-O2.Na

Molecular Weight

  • 322.4213
 

Classification Code

  • Reproductive Effect
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Names and Synonyms

Synonyms

  • Retinoic acid, sodium salt
  • Sodium retinoate
  • Vitamin A acid sodium salt

Systematic Name

  • Retinoic acid, all-trans-, sodium salt

Registry Numbers

CAS Registry Number

  • 13497-05-7

Related Registry Number

  • 302-79-4 (Parent)

System Generated Number

  • 0013497057

Molecular Formulas

Molecular Formula

  • C20-H27-O2.Na

Molecular Formula Fragments

  • C20-H27-O2
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C20H28O2.Na/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5;/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22);/q;+1/p-1/b9-6+,12-11+,15-8+,16-14+;

InChIKey

MLZFHHXDDHGSIR-ABAXVIISSA-M

Smiles

[Na+].C\C(=C/C=C/C(=C/C(=O)[O-])/C)\C=C\C1=C(C)CCCC1(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LDLo intravenous 34mg/kg (34mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Teratology, The International Journal of Abnormal Development. Vol. 5, Pg. 103, 1972.