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Substance Name: Asparaginase erwinia chrysanthemi [USAN]
RN: 1349719-22-7
UNII: D733ET3F9O

Note

  • A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3.

    NCI: Asparaginase Erwinia chrysanthemi. An enzyme isolated from the bacterium Erwinia chrysanthemi (E. carotovora). Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting leukemic cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. This agent also induces apoptosis in tumor cells. The Erwinia-derived product is often used for those patients who have experienced a hypersensitivity reaction to the E. Coli formulation. (NCI Thesaurus)
 

Classification Code

  • Antineoplastic Agents

Names and Synonyms

Name of Substance

  • Asparaginase erwinia chrysanthemi [USAN]
  • Crisantaspase [INN]

Synonyms

  • Asparaginase (erwinia chrysanthemi)
  • Asparaginase erwinia chrysanthemi
  • Asparaginase erwinia chrysanthemi [USAN]
  • Asparaginase erwinia sp. [MI]
  • Crisantaspase
  • Crisantaspase [INN]
  • Erwinase
  • Erwinaze
  • Erwinia asparaginase
  • L-Asparaginase (ec 3.5.1.1, L-asparagine amidohydrolase) erwinia chrysanthemi tetramer alpha4
  • L-Asparaginase (erwinia)
  • L-Asparaginase, erwinia chrysanthemi
  • UNII-D733ET3F9O

Registry Numbers

CAS Registry Number

  • 1349719-22-7

FDA UNII

  • D733ET3F9O

System Generated Number

  • 1349719227