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Substance Name: Hydroflumethiazide [USP:INN:BAN:JAN]
RN: 135-09-1
UNII: 501CFL162R
InChIKey: DMDGGSIALPNSEE-UHFFFAOYSA-N

Note

  • A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)

Molecular Formula

  • C8-H8-F3-N3-O4-S2

Molecular Weight

  • 331.2942
 

Classification Codes

  • Antihypertensive
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Diuretic
  • Diuretics
  • Drug / Therapeutic Agent
  • Membrane Transport Modulators
  • Natriuretic Agents
  • Sodium Chloride Symporter Inhibitors

Names and Synonyms

Name of Substance

  • Hydroflumethiazide
  • Hydroflumethiazide [USP:INN:BAN:JAN]

MeSH Heading

  • Hydroflumethiazide

Synonyms

  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide
  • 3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 3,4-Dihydro-6-trifluoromethyl-7-sulfamoylbenzo-1,2,4-thiadiazine 1,1-dioxide
  • 3,4-Dihydro-7-sulfamyl-6-trifluoromethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • 4-27-00-08035 (Beilstein Handbook Reference)
  • 6-Trifluoromethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • 6-Trifluoromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide
  • 7-Sulfamyl-6-trifluoromethyl-3,4-dihydro-1,2,4-benzothiadiazine 1, 1-dioxide
  • 7-Sulfamyl-6-trifluoromethyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
  • Bristab
  • Bristurin
  • BRN 0342692
  • Di-ademil
  • Di-adenil
  • Dihydroflumethiazide
  • Diucardin
  • Diuredemina
  • Diurometon
  • EINECS 205-173-8
  • Elodrin
  • Elodrine
  • Enjit
  • Finuret
  • Flutizide
  • Glomerulin
  • Hidroalogen
  • Hidroflumetiazid
  • Hidroflumetiazida
  • Hidroflumetiazida [INN-Spanish]
  • HSDB 3340
  • Hydol
  • Hydrenox
  • Hydroflumethiazide
  • Hydroflumethiazidum
  • Hydroflumethiazidum [INN-Latin]
  • Hydroflumethizide
  • Idroflumetiazide
  • Idroflumetiazide [DCIT]
  • Leodrine
  • Metforylthiadiazin
  • Metforylthiazidin
  • Naciex (glaxo)
  • NaClex
  • NSC 44627
  • Olmagran
  • Rivosil
  • Robezon
  • Rodiuran
  • Rontyl
  • Saluron
  • Sisuril
  • Spandiuril
  • Trifluoromethylhydrazide
  • Trifluoromethylhydrothiazide
  • UNII-501CFL162R
  • Vergonil

Systematic Names

  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide
  • Hydroflumethiazide

Mixture Name

  • Salutensin

Registry Numbers

CAS Registry Number

  • 135-09-1

FDA UNII

  • 501CFL162R

System Generated Number

  • 0000135091

Structure Descriptors

InChI

1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)

InChIKey

DMDGGSIALPNSEE-UHFFFAOYSA-N

Smiles

NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1C(F)(F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 6280mg/kg (6280mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961.
mouse LD50 intravenous 750mg/kg (750mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 134, Pg. 273, 1961.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Drugs in Japan Vol. 6, Pg. 629, 1982.
mouse LD50 parenteral 1182mg/kg (1182mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD French Medicament Patent Document. Vol. #80M,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 270.5 deg C   EXP
pKa Dissociation Constant 8.9 (none)   EXP
log P (octanol-water) 0.36 (none)   EXP
Water Solubility 300 mg/L 25 EXP
Vapor Pressure 4.49E-10 mm Hg 25 EST
Henry's Law Constant 5.15E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 8.11E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.