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Substance Name: Methapyrilene hydrochloride [USP]
RN: 135-23-9
UNII: 00S42N58OM
InChIKey: BONORRGKLJBGRV-UHFFFAOYSA-N

Note

  • Histamine H1 antagonist with sedative action used as a hypnotic and in allergies.

Molecular Formula

  • C14-H19-N3-S.Cl-H

Molecular Weight

  • 297.852
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Tumor Data
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Names and Synonyms

Name of Substance

  • Methapyrilene hydrochloride [USP]

Synonyms

  • 1,2-Ethanediamine, N,N-dimethyl-N'-2-pyridinyl-N'-(2-thienylmethyl)-, monohydrochloride
  • 2-((2-(Dimethylamino)ethyl)-2-thenyl-amino)pyridine hydrochloride
  • 2-((2-(Dimethylamino)ethyl)-2-thenylamino)pyridine monohydrochloride
  • Barhist
  • Blue Line
  • Capathyn
  • CCRIS 379
  • Compound 01013
  • Coryzol
  • Dozar
  • EINECS 205-184-8
  • Ethylenediamine, N,N-dimethyl-N'-(2-pyridyl)-N'-(2-thenyl)-, hydrochloride
  • Histadyl
  • Histafed
  • Lullamin
  • Methacon
  • Methapyrilene HCl
  • Methapyrilene hydrochloride
  • Methoxylene
  • N,N-Dimethyl-N'-(2-pyridyl)-N'-(2-thenyl)ethylenediamine hydrochloride
  • N,N-Dimethyl-N'-(2-thenyl)-N'-(2-pyridyl-ethylene-diamine hydrochloride)
  • Pyrathyn
  • Semikon hydrochloride
  • Somnicaps
  • Tem-Histine
  • Teralin
  • Thenylene hydrochloride
  • Thenylpyramine hydrochloride
  • UNII-00S42N58OM
  • W-53 hydrochloride

Systematic Names

  • 1,2-Ethanediamine, N,N-dimethyl-N'-2-pyridinyl-N'-(2-thienylmethyl)-, monohydrochloride
  • 1,2-Ethanediamine, N1,N1-dimethyl-N2-2-pyridinyl-N2-(2-thienylmethyl)-, hydrochloride (1:1)
  • Methapyrilene hydrochloride
  • Pyridine, 2-((2-(dimethylamino)ethyl)-2-thenylamino)-, monohydrochloride

Superlist Name

  • Methapyrilene hydrochloride

Registry Numbers

CAS Registry Number

  • 135-23-9

FDA UNII

  • 00S42N58OM

Other Registry Number

  • 8048-01-9

System Generated Number

  • 0000135239

Molecular Formulas

Molecular Formula

  • C14-H19-N3-S.Cl-H

Molecular Formula Fragments

  • C14-H19-N3-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C14H19N3S.ClH/c1-16(2)9-10-17(12-13-6-5-11-18-13)14-7-3-4-8-15-14;/h3-8,11H,9-10,12H2,1-2H3;1H

InChIKey

BONORRGKLJBGRV-UHFFFAOYSA-N

Smiles

CN(C)CCN(Cc1cccs1)c2ccccn2.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 14600ug/kg (14.6mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958.
man TDLo oral 429ug/kg (0.429mg/kg) GASTROINTESTINAL: GASTRITIS Journal of Pharmacology and Experimental Therapeutics. Vol. 90, Pg. 83, 1947.
mouse LD50 intraperitoneal 90mg/kg (90mg/kg) BEHAVIORAL: EXCITEMENT

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Bulletin of the Johns Hopkins Hospital. Vol. 81, Pg. 55, 1947.
mouse LD50 intravenous 17500ug/kg (17.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 210, 1948.
mouse LD50 oral 182mg/kg (182mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 90, Pg. 83, 1947.
mouse LD50 subcutaneous 75mg/kg (75mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 210, 1948.
rat LD50 oral 200mg/kg (200mg/kg)   Journal of Pharmaceutical Sciences. Vol. 59, Pg. 1131, 1970.
rat LD50 subcutaneous 150mg/kg (150mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 73, 1969.