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Substance Name: Piperoxan hydrochloride
RN: 135-87-5
UNII: KS0DZ1UQNW
InChIKey: BITRJBQGQMGGQI-UHFFFAOYSA-N

Note

  • A benzodioxane alpha-adrenergic blocking agent with considerable stimulatory action. It has been used to diagnose PHEOCHROMOCYTOMA and as an antihypertensive agent.

Molecular Formula

  • C14-H19-N-O2.Cl-H

Molecular Weight

  • 269.77
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Piperoxan hydrochloride

Synonyms

  • 1,4-Benzodioxan, 2-(1-piperidylmethyl)-, hydrochloride
  • 1-(1,4-Benzodioxan-2-ylmethyl)piperidine hydrochloride
  • 2-(1-Piperidylmethyl)-1,4-benzodioxan hydrochloride
  • 2-Piperidinomethyl-1,4-benzodioxan hydrochloride
  • 933F
  • 933F hydrochloride
  • Benodaine hydrochloride
  • Benzodioxane hydrochloride
  • EINECS 205-222-3
  • F 933 hydrochloride
  • Fourneau 933 hydrochloride
  • Piperoxan HCl
  • Piperoxan hydrochloride
  • Piperoxane hydrochloride
  • UNII-KS0DZ1UQNW

Systematic Names

  • 1-((2,3-Dihydro-1,4-benzodioxin-2-yl)methyl)piperidinium chloride
  • Piperidine, 1-(1,4-benzodioxan-2-ylmethyl)-, hydrochloride

Registry Numbers

CAS Registry Number

  • 135-87-5

FDA UNII

  • KS0DZ1UQNW

System Generated Number

  • 0000135875

Molecular Formulas

Molecular Formula

  • C14-H19-N-O2.Cl-H

Molecular Formula Fragments

  • C14-H19-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C14H19NO2.ClH/c1-4-8-15(9-5-1)10-12-11-16-13-6-2-3-7-14(13)17-12;/h2-3,6-7,12H,1,4-5,8-11H2;1H

InChIKey

BITRJBQGQMGGQI-UHFFFAOYSA-N

Smiles

c12O[C@@H](CN3CCCCC3)COc1cccc2.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 175mg/kg (175mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 48, Pg. 409, 1959.
mouse LD50 intravenous 26mg/kg (26mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 105, Pg. 221, 1956.
mouse LD50 oral 502mg/kg (502mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 48, Pg. 409, 1959.
mouse LD50 subcutaneous 500mg/kg (500mg/kg) BEHAVIORAL: ANALGESIA Therapie. Vol. 13, Pg. 17, 1958.