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Substance Name: Sarpogrelate hydrochloride [JAN]
RN: 135159-51-2
UNII: FQN8N8QP1B
InChIKey: POQBIDFFYCYHOB-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Fibrinolytic Agents
  • Platelet Aggregation Inhibitors
  • Reproductive Effect
  • Serotonin Antagonists

Molecular Formula

  • C24-H31-N-O6.Cl-H

Molecular Weight

  • 465.9708
 
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Names and Synonyms

Name of Substance

  • Sarpogrelate hydrochloride
  • Sarpogrelate hydrochloride [JAN]

Synonyms

  • Anplag
  • MCI 9042
  • MCI-9042
  • Sarpogrelate HCl
  • Sarpogrelate hydrochloride
  • UNII-FQN8N8QP1B

Systematic Names

  • Butanedioic acid, esters, mono(2-(dimethylamino)-1-((2-(2-(3-methoxyphenyl)ethyl)phenoxy)methyl)ethyl) ester, hydrochloride, (+-)-
  • Butanedioic acid, mono(2-(dimethylamino)-1-((2-(2-(3-methoxyphenyl)ethyl)phenoxy)methyl)ethyl) ester, hydrochloride, (+-)-

Registry Numbers

CAS Registry Number

  • 135159-51-2

FDA UNII

  • FQN8N8QP1B

Other Registry Number

  • 86819-20-7

System Generated Number

  • 0135159512

Molecular Formulas

Molecular Formula

  • C24-H31-N-O6.Cl-H

Molecular Formula Fragments

  • C24-H31-N-O6
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C24H31NO6.ClH/c1-25(2)16-21(31-24(28)14-13-23(26)27)17-30-22-10-5-4-8-19(22)12-11-18-7-6-9-20(15-18)29-3;/h4-10,15,21H,11-14,16-17H2,1-3H3,(H,26,27);1H

InChIKey

POQBIDFFYCYHOB-UHFFFAOYSA-N

Smiles

CN(C)CC(COc1ccccc1CCc2cccc(c2)OC)OC(=O)CCC(=O)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 3gm/kg (3000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl,
mouse LD50 intraperitoneal 65mg/kg (65mg/kg) GASTROINTESTINAL: PERITONITIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl,
mouse LD50 intraperitoneal 330mg/kg (330mg/kg)   Journal of Medicinal Chemistry. Vol. 33, Pg. 1818, 1990.
mouse LD50 intravenous > 45mg/kg (45mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl,
mouse LD50 oral 2gm/kg (2000mg/kg)   European Patent Application. Vol. #0072942,
mouse LD50 oral 2550mg/kg (2550mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl,
rat LD50 intraperitoneal 108mg/kg (108mg/kg) GASTROINTESTINAL: PERITONITIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl,
rat LD50 intravenous > 45mg/kg (45mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl,
rat LD50 oral 4400mg/kg (4400mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl,