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Substance Name: Pindolol [USAN:USP:INN:BAN:JAN]
RN: 13523-86-9
UNII: BJ4HF6IU1D
InChIKey: JZQKKSLKJUAGIC-UHFFFAOYSA-N

Note

  • A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)

Molecular Formula

  • C14-H20-N2-O2

Molecular Weight

  • 248.324
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Antagonists
  • Adrenergic beta-Antagonists
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Neurotransmitter Agents
  • Reproductive Effect
  • Serotonin Agents
  • Serotonin Antagonists
  • Vasodilator
  • Vasodilator Agents

Names and Synonyms

Name of Substance

  • Pindolol
  • Pindolol [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Pindolol

Synonyms

  • (+-)-Pindolol
  • 1-((1-Methylethyl)amino)-3-(4-indolyloxy)-2-propanol
  • 1-(1H-Indol-4-yloxy)-3-((1-methylethyl)amino)-2-propanol
  • 1-(Indol-4-yloxy)-3-(isopropylamino)-2-propanol
  • 2-Propanol, 1-(1H-indol-4-yloxy)-3-(1-methylethyl)amino-
  • 2-Propanol, 1-(4-indolyloxy)-3-(isopropylamino)-
  • 4-(2-Hydroxy-3-isopropylaminopropoxy)-indole
  • 4-(3-(Isopropylamino)-2-hydroxypropoxy)indole
  • 5-21-03-00017 (Beilstein Handbook Reference)
  • Betapindol
  • Blocklin L
  • BRN 1536506
  • Calvisken
  • Carvisken
  • CCRIS 9215
  • Decreten
  • Durapindol
  • EINECS 236-867-9
  • EINECS 244-623-8
  • Glauco-Viskin
  • HSDB 6539
  • LB 46
  • LB-46
  • Pectobloc
  • Pinbetol
  • Pindolol
  • Pindololum
  • Pindololum [INN-Latin]
  • Prinodolol
  • Pynastin
  • UNII-BJ4HF6IU1D
  • Visken

Systematic Names

  • (1)-1-(1H-Indol-4-yloxy)-3-(isopropylamino)propan-2-ol
  • 2-Propanol, 1-(1H-indol-4-yloxy)-3-((1-methylethyl)amino)-
  • 2-Propanol, 1-(indol-4-yloxy)-3-(isopropylamino)-, (+-)-
  • Pindolol

Registry Numbers

CAS Registry Number

  • 13523-86-9

FDA UNII

  • BJ4HF6IU1D

Other Registry Number

  • 21870-06-4

System Generated Number

  • 0013523869

Structure Descriptors

InChI

1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3

InChIKey

JZQKKSLKJUAGIC-UHFFFAOYSA-N

Smiles

CC(C)NCC(COc1cccc2c1cc[nH]2)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 71ug/kg/1D-I (0.071mg/kg) BEHAVIORAL: TREMOR Postgraduate Medical Journal. Vol. 56, Pg. 346, 1980.
mouse LD50 intraperitoneal 80mg/kg (80mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9, Pg. 3573, 1981.
mouse LD50 intravenous 22600ug/kg (22.6mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 794, 1978.
mouse LD50 oral 235mg/kg (235mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Toxicological Sciences. Vol. 6, Pg. 301, 1981.
mouse LD50 subcutaneous 336mg/kg (336mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Niigata Igakkai Zasshi. Niigata Medical Journal. Vol. 84, Pg. 438, 1970.
rabbit LD50 intravenous 10mg/kg (10mg/kg)   Niigata Igakkai Zasshi. Niigata Medical Journal. Vol. 84, Pg. 438, 1970.
rabbit LD50 oral 650mg/kg (650mg/kg)   Niigata Igakkai Zasshi. Niigata Medical Journal. Vol. 84, Pg. 438, 1970.
rat LD50 intraperitoneal 110mg/kg (110mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
rat LD50 intravenous 51mg/kg (51mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Niigata Igakkai Zasshi. Niigata Medical Journal. Vol. 84, Pg. 438, 1970.
rat LD50 oral 263mg/kg (263mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Niigata Igakkai Zasshi. Niigata Medical Journal. Vol. 84, Pg. 438, 1970.
rat LD50 subcutaneous 251mg/kg (251mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Niigata Igakkai Zasshi. Niigata Medical Journal. Vol. 84, Pg. 438, 1970.
women TDLo oral 300ug/kg/3D-I (0.3mg/kg) BEHAVIORAL: TREMOR Postgraduate Medical Journal. Vol. 56, Pg. 346, 1980.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 167-171 deg C   EXP
log P (octanol-water) 1.75 (none)   EXP
Water Solubility 7880 mg/L 25 EST
Vapor Pressure 1.23E-08 mm Hg 25 EST
Henry's Law Constant 1.34E-15 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.09E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.