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Substance Name: Apazone [USAN]
RN: 13539-59-8
UNII: K2VOT966ZI
InChIKey: MPHPHYZQRGLTBO-UHFFFAOYSA-N
Note
- An anti-inflammatory agent used in the treatment of rheumatoid arthritis. It also has uricosuric properties and has been used to treat gout.
Molecular Formula
- C16-H20-N4-O2
Molecular Weight
- 300.36
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Drug / Therapeutic Agent
- Gout Suppressants
- Human Data
- Peripheral Nervous System Agents
- Renal Agents
- Sensory System Agents
- Uricosuric Agents
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Names and Synonyms
Name of Substance
- Apazone
- Apazone [USAN]
- Azapropazone [INN]
MeSH Heading
- Apazone
Synonyms
- 1,2-Dihydro-3-dimethylamino-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine
- 1H-Pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-
- 3-Dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine
- 5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione
- AHR 3018
- AHR-3018
- Apazone
- Azapropazon
- Azapropazon [German]
- Azapropazona
- Azapropazona [INN-Spanish]
- Azapropazone
- Azapropazone (anhydrous)
- Azapropazonum
- Azapropazonum [INN-Latin]
- BRN 0623763
- Cinnamin
- Cinnopropazone
- EINECS 236-913-8
- MI 85
- Mi-85
- Mitrolan
- NSC 102824
- NSC-102824
- Prolix
- Prolixan
- Prolixan 300
- Rheumox
- Sinnamin
- UNII-K2VOT966ZI
- Xani
Systematic Names
- 1H-Pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-
- Azapropazone
Registry Numbers
CAS Registry Number
- 13539-59-8
FDA UNII
- K2VOT966ZI
Related Registry Number
- 22304-30-9 (di-hydrate)
System Generated Number
- 0013539598
Structure Descriptors
InChI
1S/C16H20N4O2/c1-5-6-11-14(21)19-13-9-10(2)7-8-12(13)17-16(18(3)4)20(19)15(11)22/h7-9,11H,5-6H2,1-4H3InChIKey
MPHPHYZQRGLTBO-UHFFFAOYSA-NSmiles
CCCC1C(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD50 | intravenous | 500mg/kg (500mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976. |
mouse | LD50 | intraperitoneal | 920mg/kg (920mg/kg) | Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976. | |
mouse | LD50 | intravenous | 680mg/kg (680mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976. |
mouse | LD50 | oral | 1080mg/kg (1080mg/kg) | Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976. | |
rat | LD50 | intraperitoneal | 650mg/kg (650mg/kg) | Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976. | |
rat | LD50 | intravenous | 660mg/kg (660mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Current Medical Research and Opinion. Vol. 4, Pg. 17, 1976. |
rat | LD50 | oral | 1800mg/kg (1800mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 15, Pg. 41, 1978. | |
women | TDLo | oral | 52560mg/kg/3Y (52560mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | British Medical Journal. Vol. 292, Pg. 97, 1986. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 247 | deg C | EXP | |
log P (octanol-water) | -0.030 | (none) | EST | |
Water Solubility | 147 | mg/L | 35 | EXP |
Atmospheric OH Rate Constant | 1.17E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.