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Substance Name: Lenograstim [USAN:INN:BAN]
RN: 135968-09-1
UNII: 6WS4C399GB

Note

  • Component 1 and Component 2 differ by absence or presence of Neu5Ac in 2-6 linkage to GalNAc side chain.

Molecular Formula

  • Unspecified

Molecular Weight

  • 18667.587
 

Classification Codes

  • Adjuvants, Immunologic
  • Antineutropenic
  • Drug / Therapeutic Agent
  • Hematopoietic Stimulant
  • Human Data
  • Immunologic Factors
  • Natural Product
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Links to Resources

Names and Synonyms

Name of Substance

  • Lenograstim
  • Lenograstim [USAN:INN:BAN]

Synonyms

  • (Component 1) Colony-stimulating factor (human clone 1034), 133-(O-(O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-3)-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl)-L-threonine)-; (Component 2) Colony-stimulating factor (human clone 1034), 133-(O-(O-(N-acetyl-alpha-neuraminosyl)-(2-6)-O-(O-(N-acetyl-alpha-neuraminosyl)-(2-3)-beta-D-galactopyranosyl-(1-3))-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl)-L-threonine)-
  • 133-(O-(O-(N-Acetyl-alpha-neuraminosyl)-(2-3)-(O-beta-D-galactopyranosyl-(1-3))-2-acetamido-2-deoxy-beta-D-galactopyranosyl)-L-threonine)colony-stimulating factor (human clone 1034) mixture with 133-(O-(O-(N-acetyl-alpha-neuraminosyl)-(2-6)-O-(O-(N-acetyl-alpha-neuraminosyl)-(2-3)-beta-D-galactopyranosyl-(1-3))-2-acetamido-2-deoxy-beta-D-galactopyranosyl)-L-threonine)colony-stimulating factor (human clone 1034)
  • Lenograstim
  • Neutrogin
  • rG-CSF
  • UNII-6WS4C399GB

Systematic Name

  • Lenograstim

Registry Numbers

CAS Registry Number

  • 135968-09-1

FDA UNII

  • 6WS4C399GB

System Generated Number

  • 0135968091

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous > 5mg/kg (5mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
dog LD50 subcutaneous > 5mg/kg (5mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
man TDLo subcutaneous 21428mg/kg/15 (21428mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" Internal Medicine. Vol. 33, Pg. 641, 1994.
rat LD50 intravenous > 5mg/kg (5mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat LD50 oral > 5mg/kg (5mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.
rat LD50 subcutaneous > 5mg/kg (5mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 93, 1992.