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Substance Name: Tetracaine hydrochloride [USP:JAN]
RN: 136-47-0
UNII: 5NF5D4OPCI
InChIKey: PPWHTZKZQNXVAE-UHFFFAOYSA-N

Note

  • A potent local anesthetic of the ester type used for surface and spinal anesthesia.

Molecular Formula

  • C15-H24-N2-O2.Cl-H

Molecular Weight

  • 300.828
 

Classification Codes

  • Anesthetic (Local)
  • Drug / Therapeutic Agent
  • Mutation Data
  • Skin / Eye Irritant
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Names and Synonyms

Name of Substance

  • Leocaine
  • Tetracaine hydrochloride
  • Tetracaine hydrochloride [USP:JAN]

Synonyms

  • 2-(Dimethylamino)ethyl p-(butylamino)benzoate hydrochloride
  • 2-(Dimethylamino)ethyl p-(butylamino)benzoate monohydrochloride
  • 2-Dimethylaminoethanol 4-N-butylaminobenzoate hydrochloride
  • Amethocaine hydrochloride
  • Amethocaine monohydrochloride
  • Anacel
  • Anethain
  • Anethaine
  • Butethanol
  • Butylocaine
  • Curtacain
  • Decicain
  • Decicaine
  • Dessicain
  • Dicaine
  • Dicainum
  • Dikain
  • EINECS 205-248-5
  • Gingicain M
  • Intercaine
  • Leocaine
  • Menonasal
  • Niphanoid
  • p-(Butylamino)benzoic acid, 2-(dimethylamino)ethyl ester, hydrochloride
  • p-Butylaminobenzoyl-2-dimethylaminoethanol hydrochloride
  • Pantocain
  • Pantocaine
  • Pontocaine Hydrochloride
  • Tetracaine chlorhydrate
  • Tetracaine HCl
  • Tetracaine hydrochloride
  • Tetracaine monohydrochloride
  • Tetracainium chloridum
  • Tonexol
  • UNII-5NF5D4OPCI

Systematic Names

  • Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester, monohydrochloride
  • Benzoic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester, monohydrochloride
  • Tetracaine hydrochloride

Superlist Name

  • Tetracaine hydrochloride

Mixture Names

  • Exactacain
  • Fulvidex (Veterinary)

Registry Numbers

CAS Registry Number

  • 136-47-0

FDA UNII

  • 5NF5D4OPCI

Other Registry Numbers

  • 2706-41-4
  • 41585-83-5

Related Registry Number

  • 94-24-6 (Parent)

System Generated Number

  • 0000136470

Molecular Formulas

Molecular Formula

  • C15-H24-N2-O2.Cl-H

Molecular Formula Fragments

  • C15-H24-N2-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H

InChIKey

PPWHTZKZQNXVAE-UHFFFAOYSA-N

Smiles

c1(C(OCCN(C)C)=O)ccc(NCCCC)cc1.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 4mg/kg (4mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 739, 1957.
guinea pig LD50 subcutaneous 19500ug/kg (19.5mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 20, Pg. 380, 1947.
mouse LD50 intraperitoneal 23mg/kg (23mg/kg)   Archiv der Pharmazie Vol. 321, Pg. 115, 1988.
mouse LD50 intravenous 6400ug/kg (6.4mg/kg)   Drugs in Japan Vol. -, Pg. 815, 1995.
mouse LD50 oral 160mg/kg (160mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: MUSCLE WEAKNESS
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 413, 1975.
mouse LD50 subcutaneous 25mg/kg (25mg/kg)   Pharmacology and Toxicology. English translation of FATOAO. Vol. 22, Pg. 138, 1959.
rabbit LD50 intratracheal 4400ug/kg (4.4mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 87, 1961.
rabbit LD50 intravenous 2150ug/kg (2.15mg/kg)   Drugs in Japan Vol. 6, Pg. 490, 1982.
rabbit LD50 subcutaneous 15mg/kg (15mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 388, 1948.
rabbit LDLo intraspinal 5mg/kg (5mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 57, Pg. 221, 1936.
rat LD50 intraperitoneal 23500ug/kg (23.5mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 413, 1975.
rat LD50 intravenous 4500ug/kg (4.5mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 413, 1975.
rat LD50 subcutaneous 24mg/kg (24mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 413, 1975.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 147 deg C   EXP
log P (octanol-water) 0.200 (none)   EST
Atmospheric OH Rate Constant 9.46E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.