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Substance Name: Fidarestat [INN]
RN: 136087-85-9
UNII: 8SH8T1164U
InChIKey: WAAPEIZFCHNLKK-UFBFGSQYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C12-H10-F-N3-O4

Molecular Weight

  • 279.226
 
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Names and Synonyms

Name of Substance

  • Fidarestat
  • Fidarestat [INN]

Synonyms

  • (+)-(2S,4S)-6-Fluoro-2',5'-dioxospiro(chroman-4,4'-imidazolidine)-2-carboxamide
  • (2S,4S)-6-Fluoro-2',5'-dioxospiro(3,4-dihydro-2H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide
  • Aldos
  • Fidarestat
  • SK 860
  • SNK 860
  • SNK-860
  • UNII-8SH8T1164U

Systematic Names

  • Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide, 2,3-dihydro-2',5'-dioxo-6-fluoro-, (2S-cis)-
  • Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide, 6-fluoro-2,3-dihydro-2',5'-dioxo-, (2S-cis)-

Registry Numbers

CAS Registry Number

  • 136087-85-9

FDA UNII

  • 8SH8T1164U

System Generated Number

  • 0136087859

Structure Descriptors

InChI

1S/C12H10FN3O4/c13-5-1-2-7-6(3-5)12(4-8(20-7)9(14)17)10(18)15-11(19)16-12/h1-3,8H,4H2,(H2,14,17)(H2,15,16,18,19)/t8-,12-/m0/s1

InChIKey

WAAPEIZFCHNLKK-UFBFGSQYSA-N

Smiles

N1[C@]2(C(NC1=O)=O)c1c(O[C@@H](C2)C(=O)N)ccc(F)c1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 2gm/kg (2000mg/kg)   International Congress Series--Excerpta Medica. Vol. 913, Pg. 89, 1990.
rat LD50 intravenous 1gm/kg (1000mg/kg)   International Congress Series--Excerpta Medica. Vol. 913, Pg. 89, 1990.
rat LD50 oral > 2gm/kg (2000mg/kg)   International Congress Series--Excerpta Medica. Vol. 913, Pg. 89, 1990.