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Substance Name: Hydrocortisone butyrate [USAN:USP:BAN:JAN]
RN: 13609-67-1
UNII: 05RMF7YPWN
InChIKey: BMCQMVFGOVHVNG-TUFAYURCSA-N

Classification Codes

  • Dermatologic Agents
  • Drug / Therapeutic Agent
  • Glucocorticoid
  • Hormone
  • Reproductive Effect

Molecular Formula

  • C25-H36-O6

Molecular Weight

  • 432.553
 

Names and Synonyms

Name of Substance

  • Hydrocortisone 17-butyrate
  • Hydrocortisone butyrate [USAN:USP:BAN:JAN]
  • Hydrocortisone-17-butyrate

Synonyms

  • 11-beta,17-alpha,21-Trihydroxy-4-pregnene-3,20-dione 17-alpha-butyrate
  • 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate
  • Alfason
  • Bucort
  • Cortisol 17-butyrate
  • EINECS 237-093-4
  • H.17B
  • HB(sub 17)
  • Hycortate
  • Hydrocortisone 17-butyrate
  • Hydrocortisone butyrate
  • Hydrocortisone-17alpha-butyrate
  • Lacoid
  • Lacoidon
  • Laticort
  • Locoid
  • Locoid lipocream
  • Pregn-4-ene-3,20-dione, 11,21-dihydroxy-17-(1-oxobutoxy)-, (11-beta)-
  • UNII-05RMF7YPWN

Systematic Names

  • 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate
  • Cortisol, 17-butyrate
  • Pregn-4-ene-3,20-dione, 11,21-dihydroxy-17-(1-oxobutoxy)-, (11beta)-

Registry Numbers

CAS Registry Number

  • 13609-67-1

FDA UNII

  • 05RMF7YPWN

System Generated Number

  • 0013609671

Structure Descriptors

InChI

1S/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-/m0/s1

InChIKey

BMCQMVFGOVHVNG-TUFAYURCSA-N

Smiles

C1C[C@@]([C@@]2(C[C@@H]([C@@H]3[C@@]4(C(=CC(=O)CC4)CC[C@@H]3[C@H]12)C)O)C)(C(CO)=O)OC(CCC)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1550mg/kg (1550mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: HEMATURIA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 991, 1974.
mouse LD50 oral > 3gm/kg (3000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 991, 1974.
mouse LD50 subcutaneous 2150mg/kg (2150mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Toxicological Sciences. Vol. 6(Suppl,
rat LD50 intraperitoneal > 3gm/kg (3000mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 991, 1974.
rat LD50 oral > 3gm/kg (3000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 991, 1974.
rat LD50 subcutaneous > 3gm/kg (3000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

KIDNEY, URETER, AND BLADDER: HEMATURIA
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 991, 1974.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 217-220 deg C   EXP
log P (octanol-water) 3.18 (none)   EXP
Water Solubility 3.690 mg/L 25 EST
Vapor Pressure 3.43E-14 mm Hg 25 EST
Henry's Law Constant 1.10E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.16E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.