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Substance Name: Heat shock transcription factor
RN: 136111-36-9

Note

  • Heat and cold stress-inducible, transcription factors that bind to inverted 5'-NGAAN-3' pentamer DNA sequences and are regulated by poly(ADP) ribosylation. They play essential roles as transcriptional activators of the HEAT-SHOCK RESPONSE by inducing expression of large classes of MOLECULAR CHAPERONES and heat-shock proteins. They also function in DNA REPAIR; transcriptional reactivation of latent HIV-1; and pre-mRNA processing and nuclear export of HSP70 HEAT-SHOCK PROTEINS during heat stress.
 
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Names and Synonyms

Name of Substance

  • Heat shock transcription factor

MeSH Heading

  • Heat Shock Transcription Factors

Synonyms

  • Heat shock transcription factor
  • Heat-shock factor 1
  • Hsf, human
  • HSF1

Systematic Name

  • Ribonucleic acid formation factor HSF (human reduced)

Registry Numbers

CAS Registry Number

  • 136111-36-9

System Generated Number

  • 0136111369