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Substance Name: INC 280
RN: 1362837-07-7


  • NCI: An orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c-Met inhibitor INCB028060 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis. (NCI Thesaurus)

Molecular Formula

  • Unspecified
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Links to Resources

NLM Resources (File Locators)

Other Resources (Internet Locators)

Names and Synonyms

Name of Substance

  • INC 280


  • INC-280
  • INC280

Registry Numbers

CAS Registry Number

  • 1362837-07-7

System Generated Number

  • 1362837077