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Substance Name: Fendiline hydrochloride
RN: 13636-18-5
UNII: HEM3Z10IIK
InChIKey: NJXWZWXCHBNOOG-UHFFFAOYSA-N

Note

  • Coronary vasodilator; inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as antiarrhythmic and antianginal agents.

Molecular Formula

  • C23-H25-N.Cl-H

Molecular Weight

  • 351.918
 

Classification Code

  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Fendiline hydrochloride

Synonyms

  • Benzenepropanamine, gamma-phenyl-N-(1-phenylethyl)-, hydrochloride
  • Difmecor
  • EINECS 237-121-5
  • Fendiline HCl
  • Fendiline hydrochloride
  • gamma-Phenyl-N-(1-phenylethyl)benzenepropanamine hydrochloride
  • HK 137
  • N-(1-Phenylethyl)-3,3-diphenylpropylamine hydrochloride
  • N-(3,3-Diphenylpropyl)-alpha-methylbenzylamine hydrochloride
  • Phenoxan
  • Sensit
  • UNII-HEM3Z10IIK

Systematic Names

  • (3,3-Diphenylpropyl)(1-phenylethyl)ammonium chloride
  • Benzylamine, N-(3,3-diphenylpropyl)-alpha-methyl-, hydrochloride

Registry Numbers

CAS Registry Number

  • 13636-18-5

FDA UNII

  • HEM3Z10IIK

System Generated Number

  • 0013636185

Molecular Formulas

Molecular Formula

  • C23-H25-N.Cl-H

Molecular Formula Fragments

  • C23-H25-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C23H25N.ClH/c1-19(20-11-5-2-6-12-20)24-18-17-23(21-13-7-3-8-14-21)22-15-9-4-10-16-22;/h2-16,19,23-24H,17-18H2,1H3;1H

InChIKey

NJXWZWXCHBNOOG-UHFFFAOYSA-N

Smiles

C(c1ccccc1)(c1ccccc1)CC[NH2+][C@@H](c1ccccc1)C.[ClH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 14500ug/kg (14.5mg/kg)   United States Patent Document. Vol. #3262977,
mouse LD50 oral 950mg/kg (950mg/kg)   United States Patent Document. Vol. #3262977,