Substance Name: Dinutuximab [USAN:INN]
RN: 1363687-32-4
UNII: 7SQY4ZUD30
Notes
- A human-mouse chimeric monoclonal antibody directed against disialoganglioside (GD2); used for treatment of refractory neuroblastoma & osteosarcoma.
- NCI: A chimeric mouse/human monoclonal antibody with potential antineoplastic activity. Dinutuximab binds to the ganglioside GD2 and induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity against GD2-expressing tumor cells. GD2 is overexpressed in malignant melanoma, neuroblastoma, osteosarcoma, and small cell carcinoma of the lung. (NCI Thesaurus)
Classification Code
- Antineoplastic Agents
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Links to Resources
NLM Resources (File Locators)
Other Resources (Internet Locators)
Names and Synonyms
Name of Substance
- Dinutuximab [USAN:INN]
Synonyms
- Ch 14.18
- Ch 14.18UTC
- Dinutuximab
- Monoclonal antibody ch14.18
- UNII-7SQY4ZUD30
- Unituxin
Registry Numbers
CAS Registry Number
- 1363687-32-4
FDA UNII
- 7SQY4ZUD30
Other Registry Number
- 339184-14-4
System Generated Number
- 1363687324