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Substance Name: Duloxetine hydrochloride [USAN]
RN: 136434-34-9
UNII: 9044SC542W


  • A thiophene derivative and selective NEUROTRANSMITTER UPTAKE INHIBITOR for SEROTONIN and NORADRENALINE (SNRI). It is an ANTIDEPRESSIVE AGENT and ANXIOLYTIC, and is also used for the treatment of pain in patients with DIABETES MELLITUS and FIBROMYALGIA.
  • NCI: ... duloxetine, a fluoxetine derivative belonging to the class of selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SSNRIs) and exhibiting antidepressant activity. Duloxetine selectively prevents the reuptake of 5-HT and NE via transporter complexes on the pre-synaptic membrane, thereby increasing the level of these neurotransmitters within the synaptic cleft. As a result, this agent potentiates serotonergic and noradrenergic activities in the central nervous system, and alleviates depression and neuropathy sensations, such as pain and tingling. Furthermore, duloxetine does not show significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and gamma-aminobutyric acid (GABA) receptors. ... (NCI Thesaurus)

Molecular Formula

  • C18-H19-N-O-S.Cl-H

Molecular Weight

  • 333.881

Classification Codes

  • Analgesics
  • Antidepressant
  • Antidepressive Agents
  • Central Nervous System Agents
  • Dopamine Agents
  • Membrane Transport Modulators
  • Neurotransmitter Agents
  • Neurotransmitter Uptake Inhibitors
  • Peripheral Nervous System Agents
  • Psychotropic Drugs
  • Sensory System Agents
  • Serotonin and Noradrenaline Reuptake Inhibitors
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Names and Synonyms

Name of Substance

  • Duloxetine hydrochloride [USAN]

MeSH Heading

  • Duloxetine Hydrochloride


  • (+)-(S)-N-Methyl-gamma-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride
  • 2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, hydrochloride, (S)-
  • Cymbalta
  • Dulane 20
  • Duloxetine HCl
  • Duloxetine hydrochloride
  • LY 248686 HCl
  • LY248686 HCl
  • NSC 759112
  • UNII-9044SC542W

Systematic Name

  • 2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, hydrochloride, (gammaS)-

Registry Numbers

CAS Registry Number

  • 136434-34-9


  • 9044SC542W

System Generated Number

  • 0136434349

Molecular Formulas

Molecular Formula

  • C18-H19-N-O-S.Cl-H

Molecular Formula Fragments

  • C18-H19-N-O-S
  • Cl-H

Structure Descriptors