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Substance Name: Alprenolol [INN:BAN]
RN: 13655-52-2
UNII: 877K5MQ27W
InChIKey: PAZJSJFMUHDSTF-UHFFFAOYSA-N

Note

  • One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

Molecular Formula

  • C15-H23-N-O2

Molecular Weight

  • 249.352
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Antagonists
  • Adrenergic beta-Antagonists
  • Anti-Arrhythmia Agents
  • Antihypertensive Agents
  • Autonomic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Sympatholytics
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Names and Synonyms

Results Name

  • Alprenolol [INN:BAN]

Name of Substance

  • Alprenolol
  • Alprenolol [INN:BAN]

MeSH Heading

  • Alprenolol

Synonyms

  • 1-(2-Allylphenoxy)-3-isopropylamino-2-propanol
  • 1-(o-Allylphenoxy)-3-(isopropylamino)-2-propanol
  • 2-Propanol, 1-((1-methylethyl)amino)-3-(2-(2-propenyl)phenoxy)-
  • Alfeprol
  • Alfeprol [Russian]
  • Alprenolol
  • Alprenololum
  • Alprenololum [INN-Latin]
  • EINECS 237-140-9
  • UNII-877K5MQ27W

Systematic Names

  • 2-Propanol, 1-((1-methylethyl)amino)-3-(2-(2-propenyl)phenoxy)-
  • 2-Propanol, 1-(o-allylphenoxy)-3-(isopropylamino)-
  • Alprenolol

Registry Numbers

CAS Registry Number

  • 13655-52-2

FDA UNII

  • 877K5MQ27W

System Generated Number

  • 0013655522

Structure Descriptors

InChI

1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3

InChIKey

PAZJSJFMUHDSTF-UHFFFAOYSA-N

Smiles

c1ccc(c(c1)CC=C)OC[C@@H](O)CNC(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 intraperitoneal 102mg/kg (102mg/kg)   Pharmaceutical Chemistry Journal Vol. 8, Pg. 137, 1974.
mammal (species unspecified) LD50 oral 184mg/kg (184mg/kg)   Pharmaceutical Chemistry Journal Vol. 8, Pg. 137, 1974.
mouse LD50 intraperitoneal 90mg/kg (90mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 18, Pg. 151, 1983.
mouse LD50 intravenous 20mg/kg (20mg/kg) AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1022, 1977.
women LDLo oral 210mg/kg (210mg/kg)   Ugeskrift for Laeger. Doctor's Weekly. Vol. 139, Pg. 2817, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 107-109 deg C   EXP
log P (octanol-water) 3.1 (none)   EXP
Water Solubility 547 mg/L 25 EST
Vapor Pressure 7.97E-07 mm Hg 25 EST
Henry's Law Constant 1.18E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.63E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.