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Substance Name: Irinotecan hydrochloride [USAN:USP:JAN]
RN: 136572-09-3
UNII: 042LAQ1IIS
InChIKey: KLEAIHJJLUAXIQ-JDRGBKBRSA-N
Classification Codes
- Antineoplastic (DNA Topoisomerase I Inhibitor)
- Drug / Therapeutic Agent
Molecular Formula
- C33-H38-N4-O6.Cl-H.3H2-O
Molecular Weight
- 677.1905
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Names and Synonyms
Name of Substance
- Irinotecan hydrochloride [USAN:USP:JAN]
Synonyms
- (+)-7-Ethyl-10-hydroxycamptothecine 10-(1,4'-bipiperidine)-1'-carboxylate, monohydrochloride, trihydrate
- Camptosar
- Irinotecan HCl
- Irinotecan hydrochloride
- U-101,440E
- UNII-042LAQ1IIS
Systematic Name
- (1,4'-Bipiperidine)-1'-carboxylic acid, 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester, monohydrochloride, trihydrate, (S)-
Registry Numbers
CAS Registry Number
- 136572-09-3
FDA UNII
- 042LAQ1IIS
System Generated Number
- 0136572093
Molecular Formulas
Molecular Formula
- C33-H38-N4-O6.Cl-H.3H2-O
Molecular Formula Fragments
- C33-H38-N4-O6
- Cl-H
- COMPONENT
- H2-O
Structure Descriptors
InChI
1S/C33H38N4O6.ClH.3H2O/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;;;;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H;3*1H2/t33-;;;;/m0..../s1InChIKey
KLEAIHJJLUAXIQ-JDRGBKBRSA-NSmiles
O.O.O.Cl.CCc1c2CN3C(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | 40mg/kg (40mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |
mouse | LD50 | intravenous | 132mg/kg (132mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |
mouse | LD50 | oral | 1045mg/kg (1045mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |
rat | LD50 | intravenous | 83600ug/kg (83.6mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |
rat | LD50 | oral | 867mg/kg (867mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. |