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Substance Name: Nefopam [INN:BAN]
RN: 13669-70-0
UNII: 4UP8060B7J
InChIKey: RGPDEAGGEXEMMM-UHFFFAOYSA-N

Note

  • Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)

Molecular Formula

  • C17-H19-N-O

Molecular Weight

  • 253.3431
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Peripheral Nervous System Agents
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Nefopam
  • Nefopam [INN:BAN]

MeSH Heading

  • Nefopam

Synonyms

  • 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocin
  • EINECS 237-148-2
  • Fenazoxine
  • Nefopam
  • Nefopamum
  • Nefopamum [INN-Latin]
  • UNII-4UP8060B7J

Systematic Names

  • 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl- (8CI,9CI)
  • Nefopam

Registry Numbers

CAS Registry Number

  • 13669-70-0

FDA UNII

  • 4UP8060B7J

Other Registry Numbers

  • 24358-93-8
  • 69319-32-0

Related Registry Number

  • 23327-57-3 (hydrochloride)

System Generated Number

  • 0013669700

Structure Descriptors

InChI

1S/C17H19NO/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18/h2-10,17H,11-13H2,1H3

InChIKey

RGPDEAGGEXEMMM-UHFFFAOYSA-N

Smiles

c12C(c3ccccc3)OCCN(Cc1cccc2)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 17mg/kg (17mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP		 British Medical Journal. Vol. 283, Pg. 1508, 1981.
mouse LD50 intraperitoneal 50mg/kg (50mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE Drug Development and Evaluation. Vol. 3, Pg. 10, 1979.
mouse LD50 oral 180mg/kg (180mg/kg)   United States Patent Document. Vol. #4198424,
women TDLo oral 15mg/kg (15mg/kg) CARDIAC: CHANGE IN RATE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 British Medical Journal. Vol. 283, Pg. 1508, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 3.050 (none)   EST
Atmospheric OH Rate Constant 1.36E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.