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Substance Name: Nefopam [INN:BAN]
RN: 13669-70-0
UNII: 4UP8060B7J
InChIKey: RGPDEAGGEXEMMM-UHFFFAOYSA-N
Note
- Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)
Molecular Formula
- C17-H19-N-O
Molecular Weight
- 253.3431
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Analgesics
- Analgesics, Non-Narcotic
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Human Data
- Peripheral Nervous System Agents
- Sensory System Agents
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Links to Resources
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Names and Synonyms
Name of Substance
- Nefopam
- Nefopam [INN:BAN]
MeSH Heading
- Nefopam
Synonyms
- 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocin
- EINECS 237-148-2
- Fenazoxine
- Nefopam
- Nefopamum
- Nefopamum [INN-Latin]
- UNII-4UP8060B7J
Systematic Names
- 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl- (8CI,9CI)
- Nefopam
Registry Numbers
CAS Registry Number
- 13669-70-0
FDA UNII
- 4UP8060B7J
Other Registry Numbers
- 24358-93-8
- 69319-32-0
Related Registry Number
- 23327-57-3 (hydrochloride)
System Generated Number
- 0013669700
Structure Descriptors
InChI
1S/C17H19NO/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18/h2-10,17H,11-13H2,1H3InChIKey
RGPDEAGGEXEMMM-UHFFFAOYSA-NSmiles
c12C(c3ccccc3)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 17mg/kg (17mg/kg) | BEHAVIORAL: EXCITEMENT CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | British Medical Journal. Vol. 283, Pg. 1508, 1981. |
| mouse | LD50 | intraperitoneal | 50mg/kg (50mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE | Drug Development and Evaluation. Vol. 3, Pg. 10, 1979. |
| mouse | LD50 | oral | 180mg/kg (180mg/kg) | United States Patent Document. Vol. #4198424, | |
| women | TDLo | oral | 15mg/kg (15mg/kg) | CARDIAC: CHANGE IN RATE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | British Medical Journal. Vol. 283, Pg. 1508, 1981. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 3.050 | (none) | EST | |
| Atmospheric OH Rate Constant | 1.36E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.