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Substance Name: 10'-Desmethoxystreptonigrin
RN: 136803-89-9
InChIKey: ULSNCNUVHUNMCF-UHFFFAOYSA-N

Note

  • Produced by Streptomyces albus; was discovered in a screen for inhibitors of farnesylation of RAS p21 protein.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C24-H20-N4-O7

Molecular Weight

  • 476.443
 
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Names and Synonyms

Name of Substance

  • 10'-Desmethoxystreptonigrin

Synonyms

  • 10'-Demethoxystreptonigrin
  • 10'-Desmethoxystreptonigrin

Systematic Name

  • 2-Pyridinecarboxylic acid, 5-amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl)-4-(2-hydroxy-3-methoxyphenyl)-3-methyl-

Registry Numbers

CAS Registry Number

  • 136803-89-9

System Generated Number

  • 0136803899

Structure Descriptors

InChI

1S/C24H20N4O7/c1-9-14(10-5-4-6-13(34-2)20(10)29)15(25)19(28-17(9)24(32)33)12-8-7-11-18(27-12)22(31)16(26)23(35-3)21(11)30/h4-8,29H,25-26H2,1-3H3,(H,32,33)

InChIKey

ULSNCNUVHUNMCF-UHFFFAOYSA-N

Smiles

c1(c(c(c(c(n1)c1nc2C(C(=C(C(c2cc1)=O)OC)N)=O)N)c1c(c(ccc1)OC)O)C)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 8800ug/kg (8.8mg/kg)   Journal of Antibiotics. Vol. 45, Pg. 454, 1992.