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Substance Name: Thiram [USAN:INN:ISO:BSI]
RN: 137-26-8
UNII: 0D771IS0FH
InChIKey: KUAZQDVKQLNFPE-UHFFFAOYSA-N

Note

  • A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.

Molecular Formula

  • C6-H12-N2-S4

Molecular Weight

  • 240.4388
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Antifungal
  • Drug / Therapeutic Agent
  • Fungicide, Bactericide, Wood Preservative
  • Fungicides, Industrial
  • Human Data
  • Insect Attractant, Repellent and Chemosterilant
  • Mutagens
  • Mutation Data
  • Noxae
  • Pesticides
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 3
  • Reportable Quantity (RQ) = 10 lb
  • TWA 1 mg/m3; Not classifiable as a human carcinogen
  • TWA 5 mg/m3

Names and Synonyms

Results Name

  • Thiram [USAN:INN:ISO:BSI]

Name of Substance

  • Tetramethylthioperoxydicarbonic diamide
  • Tetramethylthiuram disulfide
  • Thioperoxydicarbonic diamide, tetramethyl-
  • Thiram
  • Thiram [USAN:INN:ISO:BSI]

MeSH Heading

  • Thiram

Synonyms

  • 4-04-00-00242 (Beilstein Handbook Reference)
  • Aapirol
  • Aatiram
  • Accel TMT
  • Accelerator T
  • Accelerator thiuram
  • Aceto TETD
  • AI3-00987
  • alpha,alpha'-Dithiobis(dimethylthio)formamide
  • Anles
  • Arasan
  • Arasan 42-S
  • Arasan 70
  • Arasan 70-S Red
  • Arasan 75
  • Arasan-M
  • Arasan-SF
  • Arasan-SF-X
  • Atiram
  • Attack [Antifungal]
  • Aules
  • Bis((dimethylamino)carbonothioyl) disulfide
  • Bis((dimethylamino)carbonothioyl) disulphide
  • Bis(dimethyl thiocarbamoyl)disulfide
  • Bis(dimethyl-thiocarbamoyl)-disulfid
  • Bis(dimethyl-thiocarbamoyl)-disulfid [German]
  • Bis(dimethylthiocarbamoyl) disulfide
  • Bis(dimethylthiocarbamoyl) disulphide
  • Bis(dimethylthiocarbamyl) disulfide
  • BRN 1725821
  • Caswell No. 856
  • CCRIS 1282
  • Chipco thiram 75
  • Cunitex
  • Cyuram DS
  • Delsan
  • Disolfuro di tetrametiltiourame
  • Disolfuro di tetrametiltiourame [Italian]
  • Disulfide, bis(dimethylthiocarbamoyl)
  • Disulfure de tetramethylthiourame
  • Disulfure de tetramethylthiourame [French]
  • Disulfuro di tetrametiltiourame
  • Disulfuro di tetrametiltiourame [Italian]
  • EC 205-286-2
  • EINECS 205-286-2
  • Ekagom TB
  • ENT 987
  • EPA Pesticide Chemical Code 079801
  • Falitiram
  • Fermide
  • Fermide 850
  • Fernacol
  • Fernasan
  • Fernasan A
  • Fernide
  • Flo Pro T Seed Protectant
  • FMC 2070
  • Formalsol
  • Formamide, 1,1'-dithiobis(N,N-dimethylthio-
  • Granuflo
  • Hermal
  • Hermat TMT
  • Heryl
  • Hexathir
  • HSDB 863
  • Hy-Vic
  • Kregasan
  • Mercuram
  • Methyl thiram
  • Methyl thiuramdisulfide
  • Methyl tuads
  • Methylthiuram disulfide
  • Metiur
  • Metiurac
  • Micropearls
  • N,N'-(Dithiodicarbonothioyl)bis(N-methylmethanamine)
  • N,N,N',N'-Tetramethylthiuram disulfide
  • N,N-Tetramethylthiuram disulfide
  • N,N-Tetramethylthiuram disulphide
  • Nobecutan
  • Nocceler TT
  • Normersan
  • NSC 1771
  • NSC 49512
  • NSC 59637
  • NSC 622696
  • Orac TMTD
  • Panoram 75
  • Pol-Thiuram
  • Polyram ultra
  • Pomarsol
  • Pomarsol forte
  • Pomasol
  • Puralin
  • Radothiram
  • RCRA waste number U244
  • Rezifilm
  • Royal TMTD
  • Sadoplon
  • Sadoplon 75
  • Spotrete
  • Spotrete-F
  • SQ 1489
  • Sranan-sf-X
  • Teramethylthiuram disulfide
  • Tersan
  • Tersan 75
  • Tersantetramethyldiurane sulfide
  • Tetramethyl thiuramdisulfide
  • Tetramethyl thiurane disulfide
  • Tetramethyl thiurane disulphide
  • Tetramethyl-thiram disulfid
  • Tetramethyl-thiram disulfid [German]
  • Tetramethyldiurane sulphite
  • Tetramethylenethiuram disulfide
  • Tetramethylenethiuram disulphide
  • Tetramethylthiocarbamoyldisulphide
  • Tetramethylthioperoxydicarbonic diamide
  • Tetramethylthioramdisulfide
  • Tetramethylthioramdisulfide [Dutch]
  • Tetramethylthiuram
  • Tetramethylthiuram bisulfide
  • Tetramethylthiuram bisulphide
  • Tetramethylthiuram disulfide
  • Tetramethylthiuram disulphide
  • Tetramethylthiuran disulphide
  • Tetramethylthiurane disulfide
  • Tetramethylthiurum disulfide
  • Tetramethylthiurum disulphide
  • Tetrapom
  • Tetrasipton
  • Tetrathiuram disulfide
  • Tetrathiuram disulphide
  • Thianosan
  • Thillate
  • Thimar
  • Thimer
  • Thioknock
  • Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetramethyl-
  • Thioperoxydicarbonic diamide, tetramethyl-
  • Thiosan
  • Thioscabin
  • Thiotox
  • Thiotox (fungicide)
  • Thiram
  • Thiram 75
  • Thiram 80
  • Thiram B
  • Thiramad
  • Thirame
  • Thirame [INN-French]
  • Thirampa
  • Thiramum
  • Thiramum [INN-Latin]
  • Thirasan
  • Thiulin
  • Thiulix
  • TMTDS
  • UNII-0D771IS0FH

Systematic Names

  • Disulfide, bis(dimethylthiocarbamoyl)
  • Thioperoxydicarbonic diamide (((H2N)C(S))2S2), N,N,N',N'-tetramethyl-
  • Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetramethyl-
  • Thiram

Superlist Names

  • Disulfide, bis(dimethylthiocarbamoyl)
  • RCRA waste no. U244
  • Thioperoxydicarbonic diamide ((H2N)C(S))2S2, tetramethyl-
  • Thiram

Registry Numbers

CAS Registry Number

  • 137-26-8

FDA UNII

  • 0D771IS0FH

Other Registry Numbers

  • 1135443-08-1
  • 12680-07-8
  • 12680-62-5
  • 200889-05-0
  • 39456-80-9
  • 56645-31-9
  • 66173-72-6
  • 93196-73-7

System Generated Number

  • 0000137268

Structure Descriptors

InChI

1S/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3

InChIKey

KUAZQDVKQLNFPE-UHFFFAOYSA-N

Smiles

CN(C)C(=S)SSC(=S)N(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 300mg/kg (300mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
cat LDLo oral 230mg/kg (230mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ANALGESIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 17, Pg. 349, 1921.
chicken LD50 unreported 840mg/kg (840mg/kg)   Veterinariya. Veterinary Science. Vol. 54(2), Pg. 70, 1978.
domestic animals - goat/sheep LD50 unreported 225mg/kg (225mg/kg)   Veterinariya. Veterinary Science. Vol. 54(2), Pg. 70, 1978.
human TCLo inhalation 30ug/m3/5Y-I (0.03mg/m3) CARDIAC: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE

LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI
Vrachebnoe Delo. Medical Practice. Vol. (10), Pg. 136, 1971.
mammal (species unspecified) LD50 unreported 400mg/kg (400mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(5), Pg. 29, 1980.
mouse LD50 intraperitoneal 70mg/kg (70mg/kg)   Drugs in Japan Vol. 6, Pg. 566, 1982.
mouse LD50 oral 1250mg/kg (1250mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 6(7), Pg. 28, 1962.
mouse LD50 subcutaneous 1109mg/kg (1109mg/kg)   Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 15, Pg. 507, 1990.
mouse LD50 unreported 1150mg/kg (1150mg/kg)   Kobunshi Kako. Polymer Applications. Vol. 26, Pg. 358, 1977.
rabbit LD50 oral 210mg/kg (210mg/kg)   Kobunshi Kako. Polymer Applications. Vol. 26, Pg. 358, 1977.
rabbit LD50 unreported 210mg/kg (210mg/kg)   Veterinariya. Veterinary Science. Vol. 54(2), Pg. 70, 1978.
rabbit LDLo skin 1gm/kg (1000mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 110, 1982.
rat LC50 inhalation 500mg/m3/4H (500mg/m3)   "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1027, 1986.
rat LD50 intraperitoneal 138mg/kg (138mg/kg)   Journal de Pharmacologie. Vol. 9, Pg. 35, 1978.
rat LD50 intraperitoneal 138mg/kg (138mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Journal de Pharmacologie. Vol. 9, Pg. 35, 1978.
rat LD50 oral 560mg/kg (560mg/kg)   Toxicology and Applied Pharmacology. Vol. 11, Pg. 546, 1967.
rat LD50 subcutaneous 646mg/kg (646mg/kg)   Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 15, Pg. 507, 1990.
rat LD50 unreported 740mg/kg (740mg/kg)   Kobunshi Kako. Polymer Applications. Vol. 26, Pg. 358, 1977.
rat LDLo skin 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 15(Suppl,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 155.6 deg C   EXP
log P (octanol-water) 1.73 (none)   EXP
Water Solubility 30 mg/L 25 EXP
Vapor Pressure 1.73E-05 mm Hg 25 EXP
Henry's Law Constant 1.82E-07 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.62E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.