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Substance Name: Pituitary adenylate cyclase-activating peptide
RN: 137061-48-4


  • A multi-function neuropeptide that acts throughout the body by elevating intracellular cyclic AMP level via its interaction with PACAP RECEPTORS. Although first isolated from hypothalamic extracts and named for its action on the pituitary, it is widely distributed in the central and peripheral nervous systems. PACAP is important in the control of endocrine and homeostatic processes, such as secretion of pituitary and gut hormones and food intake.

Classification Codes

  • Cardiovascular Agents
  • Growth Substances
  • Neurotransmitter Agents
  • Vasodilator Agents
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Names and Synonyms

MeSH Heading

  • Pituitary adenylate cyclase-activating polypeptide


  • Peptide PACAP
  • Pituitary adenylate cyclase-activating polypeptide

Systematic Name

  • Pituitary adenylate cyclase-activating peptide

Registry Numbers

CAS Registry Number

  • 137061-48-4

System Generated Number

  • 0137061484