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Substance Name: Alprenolol hydrochloride [USAN:JAN]
RN: 13707-88-5
UNII: 2502C2OIRK
InChIKey: RRCPAXJDDNWJBI-UHFFFAOYSA-N

Note

  • One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

Molecular Formula

  • C15-H23-N-O2.Cl-H

Molecular Weight

  • 285.813
 

Classification Codes

  • Anti-Adrenergic (beta-Receptor)
  • Drug / Therapeutic Agent
  • Human Data
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Names and Synonyms

Name of Substance

  • Alprenolol hydrochloride
  • Alprenolol hydrochloride [USAN:JAN]

Synonyms

  • 1-(2-Allylphenoxy)-3-isopropylamino-2-propanol hydrochloride
  • 1-(o-Allylphenoxy)-3-(isopropylamino)-2-propanol hydrochloride
  • 1-Isopropylamino-3-(o-allylphenoxy)-2-propanol hydrochloride
  • 2-Propanol, 1-((1-methylethyl)-amino)-3-(2-(2-propenyl)phenoxy)-, hydrochloride
  • 2-Propanol, 1-((1-methylethyl)amino)-3-(2-(2-propenyl)phenoxy)-, hydrochloride
  • Alprenolol HCl
  • Alprenolol hydrochloride
  • Apllobal
  • Aptin
  • Aptine
  • Aptol duriles
  • Betaptin
  • CCRIS 1051
  • Dimacor
  • EINECS 237-244-4
  • Elpert
  • Gubernal
  • H 56/28
  • Regletin
  • UNII-2502C2OIRK
  • Yobir

Systematic Names

  • 2-Propanol, 1-((1-methylethyl)amino)-3-(2-(2-propenyl)phenoxy)-, hydrochloride
  • 2-Propanol, 1-(o-allylphenoxy)-3-(isopropylamino)-, hydrochloride
  • Alprenolol hydrochloride

Registry Numbers

CAS Registry Number

  • 13707-88-5

FDA UNII

  • 2502C2OIRK

System Generated Number

  • 0013707885

Molecular Formulas

Molecular Formula

  • C15-H23-N-O2.Cl-H

Molecular Formula Fragments

  • C15-H23-N-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C15H23NO2.ClH/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3;/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3;1H

InChIKey

RRCPAXJDDNWJBI-UHFFFAOYSA-N

Smiles

c1ccc(c(c1)CC=C)OC[C@@H](O)CNC(C)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 18mg/kg (18mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Gendai no Rinsho. Vol. 3, Pg. 614, 1969.
dog LD50 oral 383mg/kg (383mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Gendai no Rinsho. Vol. 3, Pg. 614, 1969.
dog LD50 subcutaneous 92mg/kg (92mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Gendai no Rinsho. Vol. 3, Pg. 614, 1969.
man TDLo oral 571ug/kg (0.571mg/kg) CARDIAC: CHANGE IN RATE Kyorin Igakkai Zasshi. Journal of the Kyorin Medical Society. Vol. 6, Pg. 209, 1975.
mouse LD50 intraperitoneal 90mg/kg (90mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE
Gendai no Rinsho. Vol. 3, Pg. 614, 1969.
mouse LD50 intravenous 29mg/kg (29mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Gendai no Rinsho. Vol. 3, Pg. 614, 1969.
mouse LD50 oral 184mg/kg (184mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 202, Pg. 79, 1973.
mouse LD50 subcutaneous 215mg/kg (215mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 1321, 1977.
rabbit LD50 intravenous 13mg/kg (13mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Gendai no Rinsho. Vol. 3, Pg. 614, 1969.
rabbit LD50 oral 337mg/kg (337mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 52, 1989.
rabbit LD50 subcutaneous 121mg/kg (121mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Gendai no Rinsho. Vol. 3, Pg. 614, 1969.
rat LD50 intraperitoneal 92mg/kg (92mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gendai no Rinsho. Vol. 3, Pg. 614, 1969.
rat LD50 intravenous 17mg/kg (17mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gendai no Rinsho. Vol. 3, Pg. 614, 1969.
rat LD50 oral 590mg/kg (590mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 1321, 1977.
rat LD50 subcutaneous 290mg/kg (290mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 11, Pg. 1321, 1977.