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Substance Name: Tolfenamic acid [INN:BAN:JAN]
RN: 13710-19-5
UNII: 3G943U18KM
InChIKey: YEZNLOUZAIOMLT-UHFFFAOYSA-N

Molecular Formula

  • C14-H12-Cl-N-O2

Molecular Weight

  • 261.7068
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Calcium Channel Blockers
  • Cardiovascular Agents
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Membrane Transport Modulators
  • Neurotransmitter Agents
  • Peripheral Nervous System Agents
  • Prostaglandin Antagonists
  • Reproductive Effect
  • Sensory System Agents
  • Serotonin Agents
  • Serotonin Antagonists
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Names and Synonyms

Name of Substance

  • Tolfenamic acid
  • Tolfenamic acid [INN:BAN:JAN]

Synonyms

  • 2-((3-Chloro-2-methylphenyl)amino)benzoic acid
  • Acide tolfenamique
  • Acide tolfenamique [INN-French]
  • Acido tolfenamico
  • Acido tolfenamico [INN-Spanish]
  • Acidum tolfenamicum
  • Acidum tolfenamicum [INN-Latin]
  • Bifenac
  • BRN 0657821
  • Clotam
  • EINECS 237-264-3
  • GEA 6414
  • N-(2-Methyl-3-chlorophenyl)anthranilic acid
  • N-(3-Chloro-2-methylphenyl)anthranilic acid
  • N-(3-Chloro-o-tolyl)-anthranilic acid
  • Tolfenamic acid
  • UNII-3G943U18KM

Systematic Names

  • Anthranilic acid, N-(3-chloro-o-tolyl)-
  • Benzoic acid, 2-((3-chloro-2-methylphenyl)amino)- (9CI)
  • N-(3-Chloro-o-tolyl)anthranilic acid
  • Tolfenamic acid

Registry Numbers

CAS Registry Number

  • 13710-19-5

FDA UNII

  • 3G943U18KM

System Generated Number

  • 0013710195

Structure Descriptors

InChI

1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)

InChIKey

YEZNLOUZAIOMLT-UHFFFAOYSA-N

Smiles

c1ccc(c(c1Nc1ccccc1C(=O)O)C)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 185mg/kg (185mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 838, 1983.
mouse LD50 oral 280mg/kg (280mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 838, 1983.
mouse LD50 subcutaneous 267mg/kg (267mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 838, 1983.
rabbit LD50 oral 562mg/kg (562mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 29, Pg. 851, 1983.
rat LD50 intraperitoneal 238mg/kg (238mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 29, Pg. 851, 1983.
rat LD50 oral 225mg/kg (225mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 28, Pg. 99, 1981.
rat LD50 subcutaneous 246mg/kg (246mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 838, 1983.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 207-207.5 deg C   EXP
log P (octanol-water) 5.17 (none)   EXP
Water Solubility 0.782 mg/L 25 EST
Vapor Pressure 2.59E-07 mm Hg 25 EST
Henry's Law Constant 1.73E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.81E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.