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Substance Name: Voriconazole [USAN:INN:BAN]
RN: 137234-62-9
UNII: JFU09I87TR
InChIKey: BCEHBSKCWLPMDN-MGPLVRAMSA-N

Notes

  • A triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.
  • NCI: A drug that treats infections caused by fungi. [NCI Drug Dictionary]

Molecular Formula

  • C16-H14-F3-N5-O

Molecular Weight

  • 349.315
 

Classification Codes

  • 14-alpha Demethylase Inhibitors
  • Anti-Infective Agents
  • Antifungal
  • Antifungal Agents
  • Cytochrome P-450 CYP3A Inhibitors
  • Cytochrome P-450 Enzyme Inhibitors
  • Enzyme Inhibitors
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Steroid Synthesis Inhibitors

Names and Synonyms

Name of Substance

  • Voriconazole
  • Voriconazole [USAN:INN:BAN]

MeSH Heading

  • Voriconazole

Synonyms

  • (alphaR,betaS)-alpha-(2,4-Difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
  • 4-Pyrimidineethanol, alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-, (alphaR,betaS)-
  • DRG-0301
  • UK-109,496
  • UNII-JFU09I87TR
  • VFEND
  • VFEND I.V.
  • Voriconazole
  • Vorikonazole
  • VRC

Systematic Names

  • (R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
  • 4-Pyrimidineethanol, alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-, (R-(R*,S*))-

Registry Numbers

CAS Registry Number

  • 137234-62-9

FDA UNII

  • JFU09I87TR

Other Registry Number

  • 173967-54-9

System Generated Number

  • 0137234629

Structure Descriptors

InChI

1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1

InChIKey

BCEHBSKCWLPMDN-MGPLVRAMSA-N

Smiles

c1(c([C@@]([C@H](c2ncncc2F)C)(Cn2cncn2)O)ccc(F)c1)F