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Substance Name: Talazoparib tosylate [USAN]
RN: 1373431-65-2
UNII: 02WK9U5NZC
InChIKey: QUQKKHBYEFLEHK-QNBGGDODSA-N

Note

  • Inhibits both PARP1 and PARP2

    NCI: An orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. (NCI Thesaurus)

Molecular Formula

  • C19-H14-F2-N6-O.C7-H8-O3-S

Molecular Weight

  • 552.5598
 

Classification Code

  • Treatment of Solid Tumors and Hematological Malignancies
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Names and Synonyms

Name of Substance

  • Talazoparib tosylate
  • Talazoparib tosylate [USAN]

Synonyms

  • (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido(4,3,2-de)phthalazin-3-one MONO(4-methylbenzenesulfonate)
  • 3H-Pyrido(4,3,2-de)phthalazin-3-one, 5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-, (8S,9R)-, 4-methylbenzenesulfonate (1:1)
  • BMN 673TS
  • BMN-673TS
  • Talazoparib tosylate
  • Talazoparib tosylate [USAN]
  • UNII-02WK9U5NZC

Systematic Name

  • 3H-Pyrido(4,3,2-de)phthalazin-3-one, 5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-, (8S,9R)-, 4-methylbenzenesulfonate (1:1)

Registry Numbers

CAS Registry Number

  • 1373431-65-2

FDA UNII

  • 02WK9U5NZC

System Generated Number

  • 1373431652

Structure Descriptors

InChI

1S/C19H14F2N6O.C7H8O3S/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28;1-6-2-4-7(5-3-6)11(8,9)10/h2-8,15-16,24H,1H3,(H,26,28);2-5H,1H3,(H,8,9,10)/t15-,16-;/m1./s1

InChIKey

QUQKKHBYEFLEHK-QNBGGDODSA-N

Smiles

Cc1ccc(cc1)S(=O)(=O)O.Cn1c(ncn1)[C@H]2c3c4c(cc(cc4N[C@@H]2c5ccc(cc5)F)F)c(=O)[nH]n3